Method for determining cardiac characteristics of subject

• US 6,322,514 B1
• Filed: 03/13/2000
• Issued: 11/27/2001
• Est. Priority Date: 03/13/2000
• Status: Expired due to Fees

• Current Assignee: Instrumentarium Dental Incorporated (Envista Holdings Corporation)
• Original Assignee: Instrumentarium Dental Incorporated (Envista Holdings Corporation)
• Inventors: Holte, Bo
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/524,646
• Time in Patent Office: 624 Days
• Field of Search: 600/481, 600/483, 600/484, 600/508, 600/529, 600/538, 128/204.18, 128/204.21, 128/204.23
• US Class Current: 600/481
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Abstract

A non-invasive method for determining the stroke volume of the heart, i.e. the volume of blood discharged per heart beat. A pressure transducer, is placed in a hollow organ, such as the lungs, stomach or bladder of a subject. During ventilation of, or breathing by, the subject, the incremental change in pressure in the hollow organ resulting from an incremental change in breathing gas volume in the subject'"'"'s lungs is obtained and a ratio between the two is established. The pressure change in the hollow organ caused by volumetric changes resulting from the contraction of the subject'"'"'s heart when discharging blood is also measured. The stroke volume of the subject'"'"'s heart is determined by applying the volume/pressure ratio to the pressure change resulting from the contraction of the heart.

Claims

1. A method for determining a desired physiological characteristic relating to the blood circulating action of the he art of a subject, said method comprising the steps of:

(a) carrying out an incremental change in the volume (Δ

V_L) of breathing gas in the subject'"'"'s lungs;

(b) measuring the corresponding change in pressure (Δ

P_T) in an organ of the subject, other than a blood vessel, resulting from an incremental change in breathing gas volume in the subject'"'"'s lungs;

(c) determining the relationship between an incremental change in breathing gas volume (Δ

V_L) and a resulting incremental change in pressure (Δ

P_T) in the organ;

(d) measuring the change in pressure (Δ

P_TH) in the organ caused by volumetric changes of the subject'"'"'s heart occurring from blood circulating action; and

(e) determining from the change in pressure (Δ

P_TH) and the Δ

V_L−

Δ

P_T relationship, the amount of the volumetric change in the subject'"'"'s heart and the desired physiological characteristic.

2. A method according to claim 1 wherein step (e) is further defined as determining the stroke volume (SV) of the subject'"'"'s heart.

3. A method according to claim 2 further defined as summing the stroke volumes of heart beats occurring in a predetermined period of time to determine cardiac output (CO) of the subject'"'"'s heart.

4. A method according to claim 2 wherein the determination of stroke volume is an absolute value for stroke volume (SV), said method using the value of stroke volume determined in step (e) to calibrate a relative value of stroke volume (SV) determined by a different method.

5. A method according to claim 1 wherein step (e) is further defined as determining the stroke volume (SV) for each of a plurality of heart beats of the subject and the method includes the step of subjecting the determination made in step (e) to a mathematical process to determine the desired characteristic.

6. A method according to claim 1 further defined as including the step of placing a pressure transducer in fluid communication with a hollow organ of the subject to carry out the measurements of steps (b) and (d).

7. A method according to claim 6 further defined as placing the pressure transducer in fluid communication with the hollow organ in a manner to provide frequency response characteristics sufficient to carry out the measurement of step (d).

8. A method according to claim 7 further defined as providing a frequency response of at least 2 Hz in the pressure transducer for carrying out the measurement of step (d).

9. A method according to claim 6 wherein the step of placing the pressure transducer in fluid communication with the hollow organ is further defined as placing the pressure transducer in the hollow organ.

10. A method according to claim 9 further defined as placing the pressure transducer in the hollow organ without the use of invasive surgical intervention.

11. A method according to claim 6 wherein the step of placing the pressure transducer in fluid communication with the hollow organ is further defined as placing a fluid filled member in the hollow organ for transmitting the pressure in the hollow organ to the pressure transducer.

12. A method according to claim 11 is further defined as placing one end of an elongated fluid filled member in the hollow organ with the other end extending out of the body of the subject and wherein the pressure transducer is coupled to the other end of the member for measuring pressure in the hollow organ transmitted through the fluid.

13. A method according to claim 11 further defined as placing a liquid filled member in the hollow organ.

14. A method according to claim 11 further defined as placing a gas filled member in the hollow organ.

15. A method according to claim 11 further defined as including the step of carrying out tonometric measurements in the hollow organ using the fluid filled member.

16. A method according to claim 1 further defined as carrying out the measurements of steps (b) and (d) in the lungs of the subject.

17. A method according to claim 16 wherein a breathing gas pathway extends to the subject'"'"'s lungs and wherein the measurements of steps (b) and (d) are carried out at a selected location along the breathing gas pathway.

18. A method according to claim 1 further defined as carrying out the measurements of steps (b) and (d) in a hollow organ of the subject other than the lungs.

19. A method according to claim 18 further defined as carrying out the measurements of steps (b) and (d) in the digestive tract of the subject.

20. A method according to claim 19 further defined as carrying out the measurements of steps (b) and (d) in the stomach of the subject.

21. A method according to claim 18 further defined carrying out the measurements of steps (b) and (d) in the urinary bladder of the subject.

22. A method according to claim 18 further defined as carrying out the measurements of steps (b) and (d) in the esophagus of the subject.

23. A method according to claim 1 further defined as carrying out the steps of the method on a spontaneously breathing subject.

24. A method according to claim 1 wherein step (a) is further defined as providing and removing breathing gases to/from the lungs of the subject.

25. A method according to claim 24 wherein step (a) is further defined as providing breathing gases by mechanical ventilation.

26. A method according to claim 1 wherein the subject breathes in respiratory cycles having an inspiratory phase and an expiratory phase and wherein steps (a), (b), and (d) are carried out during the expiratory phase of a respiratory cycle.

27. A method according to claim 25 wherein steps (a) and (b) are carried out in a first sampling period and step (d) is carried out in a second sampling period.

28. A method according to claim 27 wherein said second sampling period follows said first sampling period.

29. A method according to claim 1 further defined as carrying out steps (a) and (b) in a first sampling period and as carrying out step (d) in a second sampling period.

30. A method according to claim 29 wherein said second sampling period follows said first sampling period.

31. A method according to claim I wherein the volumetric change of the subject'"'"'s heart has temporal properties and wherein the method includes the step of measuring the temporal properties of the volumetric change to determine ejection time characteristics of the heart.