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Oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids

  • US 6,322,971 B1
  • Filed: 09/30/1998
  • Issued: 11/27/2001
  • Est. Priority Date: 02/19/1992
  • Status: Expired due to Term
First Claim
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1. In a method wherein first and second nucleic acid strands are ligated to each other at their termini in order to form a recombinant product, the improvement comprisinga) providing an array of immobilized oligonucleotides comprising predetermined areas on a surface of a solid support, each area having immobilized thereon copies of an oligonucleotide, b) hybridizing to said immobilized oligonucleotides first single-stranded terminal regions of first nucleic acid strands to be ligated, and c) ligating to the hybridized first termini of said hybridized first strands to said second nucleic acid strands.

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