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Surrogate genetics target characterization method

  • US 6,322,973 B1
  • Filed: 11/06/1998
  • Issued: 11/27/2001
  • Est. Priority Date: 11/07/1997
  • Status: Expired due to Fees
First Claim
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1. A method for identifying a modulator of a function of a heterologous biomolecule, comprising:

  • (a) providing a mixture of host cell populations, each population comprising a different nucleic acid molecule encoding a heterologous biomolecule selected from the group consisting of an RNA and a protein whose function has not been inferred experimentally, wherein the nucleic acid molecule is operatively associated with a promoter, wherein expression of said heterologous biomolecule from said nucleic acid molecule results in a measurable phenotype in each of said host cell populations; and

    (a) contacting said mixture of host cell populations with a test substance and detecting any changes in a measurable phenotype, wherein a change in a measurable phenotype indicates that said test substance is a potential modulator of said function of said heterologous biomolecule expressed in the host cell population whose measurable phenotype changed following said contacting.

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