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Molecular recognition at surfaces derivatized with self-assembled monolayers

  • US 6,322,979 B1
  • Filed: 04/21/1999
  • Issued: 11/27/2001
  • Est. Priority Date: 09/26/1994
  • Status: Expired due to Term
First Claim
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1. A method for capturing a biological binding partner of a nucleic acid strand in a sample, said method comprising:

  • a) providing a surface comprising;

    i) a first species having a formula X—

    R—

    NA, wherein X represents a functional group that adheres to said surface, R represents a spacer moiety that promotes formation of a self-assembled monolayer of a plurality of said species, and NA represents a nucleic acid strand; and

    ii) a second species that will form a mixed self-assembled monolayer with said first species; and

    b) contacting said surface with a medium containing a biological molecule and allowing the molecule to bind to the nucleic acid strand.

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