Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins

• US 6,323,188 B1
• Filed: 09/10/1999
• Issued: 11/27/2001
• Est. Priority Date: 07/01/1998
• Status: Expired due to Fees

• Current Assignee: Donald L. Weissman
• Original Assignee: Donald L. Weissman
• Inventors: Weissman, Donald L.
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US09/393,751
• Time in Patent Office: 809 Days
• Field of Search: 514/52, 514/165
• US Class Current: 514/52
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Disclosed is the method of reducing the incidence and severity of stroke, primary heart attack, and any subsequent heart attack or stroke in humans by daily administration of an effective amount of a combination of acetylsalicylic acid (ASA),a cyanocobalamin compound (Vitamin B12), a folic acid compound, and a pyridoxine compound (Vitamin B6) in an easy to take daily administration pack.

Claims

1. The method of reducing the incidence and severity of primary heart attack, stroke and any subsequent heart attack or stroke in humans by daily administration of an effective amount of a combination of acetylsalicylic acid (ASA),a cyanocobalamin compound (Vitamin B12), a folic acid compound, and a pyridoxine compound (Vitamin B6).

2. The method of claim 1 in which ASA is any one or more of free acetylsalicylic acid, buffered aspirin, or enteric coated aspirin in a unit dose of 41 milligrams to 200 milligrams expressed as free aspirin.

3. The method of claim 1 in which ASA is enteric coated aspirin.

4. The method of claim 1 in which the Vitamin B12 compound is in a unit dose of 25 micrograms to 800 micrograms, the folic acid compound is free folic acid in a unit dose of 300 micrograms to 1400 micrograms expressed as free folic acid, and the Vitamin B6 compound is pyridoxine hydrochloride in a unit dose of 25 milligrams to 800 milligrams.

5. The method of claim 1 in which administration of the combination is by mouth.

6. A daily administration pack for reducing the incidence and severity of stroke, primary heart attack, and any subsequent heart attack or stroke in humans, consisting essentially of an effective amount of acetylsalicylic acid (ASA), an effective amount of a cyanocobalamin compound (Vitamin B12), an effective amount of a folic acid compound, and an effective amount of a pyridoxine compound (Vitamin B6).

7. A daily administration pack according to claim 6 in which Vitamin B6, Vitamin B12 and folic acid are combined in a single unit dosage form.

8. A daily administration pack according to claim 6 in which each of ASA, Vitamin B6, Vitamin B12, and folic acid are present in a separate unit dosage form.

9. A daily administration pack according to claim 6 in which the amount of ASA is 41 milligrams to 200 milligrams expressed as free aspirin, the amount of Vitamin B6 is 25 milligrams to 500 milligrams expressed as pyridoxine), the amount of Vitamin B12 is 25 micrograms to 800 micrograms expressed as cyanocobalamin, and the amount of folic acid is 300 micrograms to 1400 microgram expressed as free folic acid.

10. A daily administration pack according to claim 6 additionally including an effective amount of at least one substance selected from the group consisting of Vitamin C antioxidant, Vitamin E antioxidant, and niacin.

11. A daily administration pack according to claim 10 in which the amount of ASA is 41 milligrams to 200 milligrams expressed as free aspirin, the amount of antioxidant when present is 0 to 2000 milligrams expressed as free ascorbic acid and/or 0 to 800 International Units expressed as Vitamin E activity, the amount of Vitamin B6 is 25 milligrams to 500 milligrams expressed as pyridoxine), the amount of Vitamin B12 is 25 micrograms to 800 micrograms expressed as cyanocobalamin, the amount of folic acid is 300 micrograms to 1400 micrograms expressed as free folic acid, and the amount of niacin when present is 0 to 700 milligrams.

12. A composition according to claim 6 for reducing the incidence and severity of stroke, primary heart attack, and any subsequent heart attack in humans consisting essentially of the active ingredients

ASA 81 milligrams

B6 50 milligrams

B12 100 micrograms

Folic acid 600 micrograms

together with 0 to 1000 milligrams of excipient and 0 to 1000 milligrams of colorant inert ingredients.