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Dolastatin peptides

  • US 6,323,315 B1
  • Filed: 03/31/2000
  • Issued: 11/27/2001
  • Est. Priority Date: 09/10/1999
  • Status: Expired due to Fees
First Claim
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1. The compound of the formula or a salt thereof with a pharmaceutically acceptable acid, whereinR1-R5 are each, independently, a hydrogen atom or a normal or branched C1-C6-alkyl group;

  • A is a phenylalanyl or phenylglycyl residue;

    n is 0 or 1;

    R6is a hydrogen atom; and

    R7 is selected from the group consisting of t-butyl, isopropyl, methyl, 2-pyridylmethyl, 3-pyridylmethyl, 4-pyridylmethyl, 2-(3-pyridyl)ethyl, 4-pyridyl, orR6 is benzyl or —

    C(O)OR8, wherein R8 is a C1-C6-alkyl group; and

    R7 is a 2-thiazolyl group.

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