Portable tissue spectroscopy apparatus and method

• US 6,324,418 B1
• Filed: 09/29/1997
• Issued: 11/27/2001
• Est. Priority Date: 09/29/1997
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Corporation
• Original Assignee: Boston Scientific Corporation
• Inventors: Crowley, Robert J., Hamm, Mark A.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/940,464
• Time in Patent Office: 1,520 Days
• Field of Search: 600/473, 600/476, 600/477, 600/478, 600/160, 600/178, 600/179, 606/14
• US Class Current: 600/476
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4233 oesophagus
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/0256 Compact construction
• CPC Class Codes: G01J 3/0272 Handheld

Abstract

A portable tissue spectroscopy apparatus includes at least one light source, at least one light detector, a power source and a controller module all disposed inside a housing that is insertable inside a body. The housing may be in the form of a hand-holdable probe or in the form of a capsule that can be swallowed or implanted in the body. The probe further includes a display mounted at a proximal end of the housing for displaying tissue characteristics. The capsule further includes a transmitter mounted inside the capsule and a receiver placed outside the body for transmitting signals representative of tissue characteristics to a remote receiver.

Claims

1. A tissue spectroscopy apparatus, comprising:

a housing insertable in a cavity of a body;

at least one light source disposed in the housing for illuminating tissue in the body, the light source emitting an output light;

at least one light detector disposed in the housing for detecting spectroscopic properties of the illuminated tissue;

a filter on each said at least one light detector, the filter admitting light within a predetermined wavelength range corresponding to a physiological characteristic of interest;

a power source disposed in the housing for powering said at least one light source and said at least one light detector; and

at least one indicator located on a proximal end of the housing for displaying an indication of the spectroscopic properties of the illuminated tissue.

2. The tissue spectroscopy apparatus of claim 1 further comprising a control module disposed in the housing in communication with the power source.

3. The tissue spectroscopy apparatus of claim 1 wherein the at least one light source comprises a light emitting diode.

4. The tissue spectroscopy apparatus of claim 3 wherein the light emitting diode is a blue light emitting diode.

5. The tissue spectroscopy apparatus of claim 1 wherein the at least one light source comprises a laser.

6. The tissue spectroscopy apparatus of claim 1 wherein the housing comprises a window disposed adjacent the at least one light source.

7. The tissue spectroscopy apparatus of claim 6 wherein a distal end of the housing is angled to provide better contact between the window and the tissue.

8. The tissue spectroscopy apparatus of claim 6 wherein the window comprises a diffuser for uniformly illuminating the tissue.

9. The tissue spectroscopy apparatus of claim 1 wherein the power source comprises a battery.

10. The tissue spectroscopy apparatus of claim 1 wherein the housing is a probe having a distal end insertable in the cavity and a hand-holdable proximal end remaining outside the body.

11. The tissue spectroscopy apparatus of claim 10 further comprising an actuator disposed adjacent the proximal end of the housing for actuating the apparatus.

12. The tissue spectroscopy apparatus of claim 10 wherein the probe comprises a flexible cover material.

13. The tissue spectroscopy apparatus of claim 1, wherein the at least one light detector comprises first and second light detectors, the first detector having a first filter admitting light within a first predetermined wavelength range and the second detector having a second filter admitting light within a second predetermined wavelength range differing from the first predetermined wavelength range.

14. The tissue spectroscopy apparatus of claim 13, wherein the at least one indicators comprises a first indicator electrically connected to the first detector, and a second indicator electrically connected to the second detector.

15. The tissue spectroscopy apparatus of claim 13, wherein the first wavelength range comprises a first wavelength of light from a cancerous tissue type when said cancerous tissue is illuminated by the at least one light source, and wherein the second wavelength range comprises a second wavelength of light from a non-cancerous tissue type when said non-cancerous tissue is illuminated by the at least one light source.

16. The tissue spectroscopy apparatus of claim 1 wherein the filter comprises a bandpass filter.

17. The tissue spectroscopy apparatus of claim 1 wherein the filter comprises a portion of the housing.

18. The tissue spectroscopy apparatus of claim 1 wherein the at least one detector is adjacent the at least one light source such that the at least one detector receives light from the at least one light source before said light interacts with the tissue.

19. The tissue spectroscopy apparatus of claim 1 wherein the predetermined wavelength range comprises a wavelength of light from a target tissue type after said target tissue type is illuminated by the at least one light source.

20. The tissue spectroscopy apparatus of claim 1 wherein the target tissue type comprises a cancerous tissue.

21. The tissue spectroscopy apparatus of claim 1 wherein the predetermined wavelength range received by the at least one detector comprises a range between about 300 nm and about 600 nm.

22. The tissue spectroscopy apparatus of claim 1, wherein the at least one light source illuminates at least at a wavelength of about 300 nm, and the predetermined wavelength range received by the at least one detector comprises a wavelength of about 360 nm.

23. The tissue spectroscopy apparatus of claim 1 wherein the at least one light source illuminates at least at a wavelength of about 435 nm, and the predetermined wavelength range received by the at least one detector comprises a range between about 500 nm and about 600 nm.

24. The tissue spectroscopy apparatus of claim 1 wherein the predetermined wavelength range is adjustable.

25. The tissue spectroscopy apparatus of claim 24 wherein the filter comprises a portion of the housing.

26. The tissue spectroscopy apparatus of claim 1 wherein the predetermined wavelength range is adjusted through adjusting the thickness of the filter.

27. The tissue spectroscopy apparatus of claim 1 wherein the filter contains a dye, and wherein the predetermined wavelength range is adjusted through adjusting the concentration of the dye.

28. The tissue spectroscopy apparatus of claim 1, further comprising an output filter disposed in a pathway of the output light, said output filter filters the output light such that the output light in an output wavelength range reaches the tissue.

29. The tissue spectroscopy apparatus of claim 28 wherein the output wavelength range comprises the range of ultraviolet light.

30. The tissue spectroscopy apparatus of claim 29 wherein the output wavelength range is adjustable.

31. The tissue spectroscopy apparatus of claim 28 wherein the output filter comprises an interference filter.

32. The tissue spectroscopy apparatus of claim 1, further comprising a frequency multiplier disposed in a pathway of the output light, said frequency multiplier amplifies the frequency of the output light.

33. The tissue spectroscopy apparatus of claim 32, wherein the frequency multiplier comprises an optically non-linear substance.

34. The tissue spectroscopy apparatus of claim 32, further comprising a wave matching layer.

35. The tissue spectroscopy apparatus of claim 1, further comprising a lens disposed in a pathway of the output light.

36. A method for performing a tissue spectroscopy, comprising:

(a) inserting a probe in a body cavity, such that a distal end of the probe is positioned adjacent a tissue, while a proximal end remains outside the body cavity;

(b) illuminating the tissue in the body with an output light emitted by at least one light source disposed in the probe;

(c) using a filter to admit input light from the illuminated tissue only within a wavelength range corresponding to a physiological characteristic of interest;

(d) detecting properties of the filtered input light with at least one light detector disposed in the probe; and

(e) displaying the detected properties on at least one indicator located on the proximal end of the probe, the properties indicating characteristics of the illuminated tissue.

37. The method of claim 36 wherein step (b) comprises illuminating the tissue with light in an ultraviolet to blue range.

38. The method of claim 36 wherein step (c) comprises admitting light in the range from about 300 nm to 500 nm.

39. The method of claim 36, wherein the filter is a bandpass filter.

40. The method of claim 36, wherein step (c) is accomplished using a portion of the probe.

41. The method of claim 36, wherein step (c) further comprises the step of adjusting the wavelength range.

42. The method of claim 41, wherein the step of adjusting the wavelength range comprises adjusting the thickness of the filter.

43. The method of claim 42, wherein the filter comprises a portion of the probe, the step of adjusting the thickness of the filter comprising repositioning the at least one detector in the probe.

44. The method of claim 41, wherein the filter contains a dye, step (c) further comprising adjusting the concentration of the dye.

45. The method of claim 44, wherein the filter comprising a portion of the probe, adjusting the concentration of the dye of the filter comprising repositioning the at least one detector in the probe.

46. The method of claim 44, wherein step (c) comprises using at least a first filter and a second filter, the first filter admitting input light expected from a cancerous tissue, the second filter admitting input light expected from a non-cancerous tissue.

47. The method of claim 46, wherein step (d) comprises using a first detector to detect light filtered by the first filter, and using a second detector to detect light filtered by the second filter.

48. The method of claim 47, wherein step (e) comprises electrically connecting a first indicator to the first detector, and electrically connecting a second indicator to the second detector.

49. The method of claim 36, wherein step (c) comprises admitting input light expected from a cancerous tissue.

50. The method of claim 36, further comprising filtering the output light before the output light reaches the tissue.

51. The method of claim 36, further comprising amplifying the output light before the output light reaches the tissue.

52. The method of claim 36, further comprising focusing the output light before the output light reaches the tissue.

53. A tissue spectroscopy apparatus, comprising:

a housing insertable in a cavity of a body;

at least one light source disposed in the housing for illuminating tissue in the body, the light source emitting an output light;

a plurality of light detectors disposed in the housing for detecting spectroscopic properties of the illuminated tissue;

a filter on at least one of the light detectors, the filter admitting light within a predetermined wavelength range corresponding to a physiological characteristic of interest;

a power source disposed in the housing for powering at least one of the light sources and at least one of the light detectors; and

an indicator located on a proximal end of the housing for displaying an indication of the spectroscopic properties of the illuminated tissue.

54. The tissue spectroscopy apparatus of claim 53, wherein the apparatus comprises first and second light detectors, the first detector having a first filter admitting light within a first predetermined wavelength range and the second detector having a second filter admitting light within a second predetermined wavelength range different from the first predetermined wavelength range.

55. The tissue spectroscopy apparatus of claim 53, wherein at least one of the plurality of detectors is adjacent the at least one light source such that the at least one of the plurality of detectors receives light from the at least one light source before said light interacts with the tissue.