Method and apparatus for therapeutic treatment of skin

• US 6,325,769 B1
• Filed: 06/28/1999
• Issued: 12/04/2001
• Est. Priority Date: 12/29/1998
• Status: Expired due to Term

• Current Assignee: DermaFocus LLC
• Original Assignee: Collapeutics, LLC
• Inventors: Klopotek, Peter J.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/340,997
• Time in Patent Office: 890 Days
• Field of Search: 601/2, 601/3, 601/4, 600/439, 604/20, 604/22, 606/27, 606/28, 606/31, 606/32
• US Class Current: 601/2
• CPC Class Codes: A61B 2017/00761 Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/027 with multiple foci created simultaneously
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method and apparatus of reducing skin wrinkles, including applying an acoustic pulse or train of pulses to a subsurface region of human skin without damaging or adversely affecting the surface or epidermis layer of the skin. The pulses cause changes in the dermis layer of the skin that result in enhanced smoothness of the epidermis layer of the skin. In particular, the acoustic pulses are applied to the dermis layer at an amplitude and for a period of time sufficient to induce production of new connective tissue that reduces or eliminate of skin wrinkles.

Claims

1. A method of rejuvenating skin, the method comprising applying an acoustic pulse to a dermis layer below a surface of a region of skin with sufficient intensity and duration, and inducing a shock wave response in the dermis layer and consequent formation of new connective tissue to cause a change in the dermis layer of the skin that results in greater smoothness at the surface of the skin.

2. The method of claim 1, wherein a step of inducing formation of new connective tissue further comprises elevating the temperature of the dermis layer.

3. The method of claim 1, wherein the step of applying an acoustic pulse further includes applying a focused ultrasound beam for a time sufficient to cause proteins in the dermis layer to denature.

4. The method of claim 1, wherein the step of applying an acoustic pulse further comprises applying a power level in the range of approximately 500 W/cm² to 1500 W/cm² within a target region of the dermis.

5. The method of claim 1, wherein the step of applying an acoustic pulse to a dermis layer further comprises focusing a ultrasound beam at a depth below the epidermis in a range between approximately 5 microns and 5 millimeters.

6. The method of claim 1, wherein the step of inducing formation of new connective tissue further comprises inducing cavitation in the dermis layer.

7. The method of claim 1, wherein a step of inducing formation of new connective tissue further comprises irritating the dermis layer without adversely damaging the epidermis layer.

8. The method of claim 1, wherein the region of skin includes a wrinkle and the method further comprises the step of scanning the focused ultrasound beam over an area occupied by the wrinkle.

9. The method of claim 8, wherein the step of scanning further comprises scanning the focused ultrasound beam over an area of the skin that is approximately ten times larger than an area of the wrinkle.

10. The method of claim 1, further comprising a step of cooling the region of skin at least one of before, during, or after the step of applying the acoustic pulse.

11. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for transmitting acoustic waves into a dermis region of skin in response to signals from a driver; and

a control device constructed and arranged to control the generator to induce shock waves in the dermis layer and the formation of new connective tissue.

12. The apparatus of claim 11, wherein the control device controls the ultrasound waves to elevate the temperature to a range and for a time sufficient to cause proteins in the dermis layer to denature.

13. The apparatus of claim 11, wherein the apparatus further comprises an acoustic lens to focus the acoustic energy at a depth below the epidermis in a range between approximately 5 micrometers and 5 millimeters.

14. The apparatus of claim 11, wherein the control device controls the acoustic waves to have at least one frequency between approximately ten megahertz and one hundred megahertz.

15. The apparatus of claim 11, wherein the apparatus further comprising a temperature sensor coupled to and providing a temperature signal to the control device.

16. The apparatus of claim 11, further comprising an acoustic receiver, coupled to at least one of the acoustic wave generator and the control device.

17. The apparatus of claim 11, further comprising a cooling device that cools the temperature of the epidermis layer.

18. The apparatus of claim 11, wherein the control device controls the acoustic waves to apply a power level in the range of approximately 500 W/cm² to 1500 W/cm² within a target region of the dermis.

19. The apparatus of claim 11, wherein the control device controls the acoustic waves to durations ranging from about 10 nanoseconds to about 200 microseconds.

20. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of of skin; and

a controller for driving the acoustic wave generator to deliver pulsed acoustic wave energy at a sufficient amplitude and frequency to induce a shock wave type response in the dermis layer.

21. The apparatus of claim 20, wherein the controller includes circuitry to drive the wave generator to deliver pulsed acoustic wave energy having at least one frequency between approximately ten megahertz and one hundred megahertz to induce a shock wave type response in the dermis layer.

22. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of a region of skin; and

a controller for driving the acoustic wave generator to deliver pulsed acoustic wave energy, the pulses ranging from about 10 nanoseconds to about 200 microseconds in duration, each pulse delivering energy in the range of about 500 W/cm² to about 1500 W/cm² at a target site in the dermis layer to induce a shock wave type response in the dermis layer.

23. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of skin;

a controller for driving the acoustic wave generator to deliver pulsed acoustic wave energy at a sufficient amplitude and frequency to induce a shock wave type response in the dermis layer; and

a linear focusing element for focusing the acoustic energy into a line such that an elongated region of the dermis layer is exposed to the acoustic wave energy.

24. The apparatus of claim 23 wherein the acoustic wave generator comprises at least one ultrasound transducer and the focusing element comprises an elongated surface of the transducer.

25. The apparatus of claim 23 wherein the acoustic wave generator comprises at least on ultrasound transducer and the focusing element comprises at least one cylindrical lens.

26. The apparatus of claim 23, wherein the focusing element focuses the ultrasound energy in a region at a depth below the epidermis in a range between approximately 5 microns and 5 millimeters.

27. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of skin;

a controller for driving the acoustic wave generator to deliver pulsed acoustic wave energy at a sufficient amplitude and frequency to induce a shock wave type response in the dermis layer; and

a focusing element for focusing the acoustic energy into the dermis layer, the focusing element having a numerical aperture ranging from about 0.1 to about 0.95.

28. The apparatus of claim 27, wherein the controller drives the acoustic wave generator to deliver pulsed acoustic wave energy at sufficient energy to elevate the temperature of a region within the dermis layer, preferably, to a range between approximately 47°

C. and 75°

C.

29. The apparatus of claim 28, wherein the controller controls the ultrasound waves to elevate a temperature of the dermis layer, preferably, to a range between approximately 55°

C. and 65°

C.

30. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of skin;

a linear focusing element for focusing the acoustic energy into a line such that an elongated region of the dermis layer is exposed to the acoustic wave energy to induce a shock wave type response in the dermis layer; and

a scanner for scanning the line through an area within the dermis layer.

31. An apparatus for rejuvenating skin, the apparatus comprising:

an acoustic wave generator for delivering acoustic wave energy into a dermis layer of of skin; and

a controller for driving the acoustic wave generator to deliver pulsed acoustic wave energy at sufficient amplitude to induce a shock wave response in the dermis layer; and

at least one feedback sensor for sensing the effect of the delivered energy and providing a signal to the controller.

32. The apparatus of claim 31, wherein the feedback sensor comprises a temperature sensor coupled to and providing a temperature signal to the controller.

33. The apparatus of claim 31, wherein the feedback sensor comprises an ultrasound receiver, coupled to the ultrasound transducer, and a signal analyzer that processes a signal received by the ultrasound receiver to provide a feedback signal to the controller.

34. The apparatus of claim 31, wherein the feedback sensor comprises an electrical conductivity sensor coupled to and providing to the control device a measure of electrical conductivity in the area of skin where ultrasound energy is being applied.

35. The apparatus of claim 31, wherein the feedback sensor comprises an audio sensor coupled to and providing to the control device an audio signal of the area of skin where ultrasound energy is being applied.

36. The apparatus of claim 35, wherein the audio sensor is a broadband microphone.

37. The apparatus of claim 31, further comprising a cooling device that cools the epidermis layer.

38. An apparatus for rejuvenating skin, the apparatus comprising:

a transducer for delivering acoustic wave energy into a dermis layer of skin; and

an acoustical waveguide disposed at a surface of the transducer, the waveguide having a thickness that defines a depth focus of the ultrasound energy in the skin;

wherein the waveguide is further arranged to apply ultrasound shock waves along a longitudinally extended area.

39. The apparatus of claim 38, wherein the waveguide further comprises a cylindrical acoustic lens for applying the ultrasound waves along the longitudinally extended area.

40. The apparatus of claim 38, wherein the waveguide further comprises an acoustically transparent plate for disposition over the area of skin to be treated so as to delimit the area to be treated.

41. The apparatus of claim 38, wherein the waveguide further comprises an acoustic focusing lens has a numerical aperture ranging from about 0.1 to about 0.95.