Inflatable cooling apparatus for selective organ hypothermia

• US 6,325,818 B1
• Filed: 10/07/1999
• Issued: 12/04/2001
• Est. Priority Date: 10/07/1999
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Werneth, Randell
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): RAM, JOCELYN D
• Application Number:
  US09/414,184
• Time in Patent Office: 789 Days
• Field of Search: 607/113, 607/105, 607/106, 606/21, 606/23, 604/96.01, 604/103.06, 604/113
• US Class Current: 607/105
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element

Abstract

A cooling apparatus having an inflatable balloon near a distal end of a multi-lumen catheter, with a plurality of blood flow passageways formed through the interior of the balloon from a proximal face of the inflated balloon to a distal face of the inflated balloon. Chilled saline solution is introduced through a supply lumen of the catheter to inflate the balloon in a feeding artery of the selected organ; this allows blood to flow through the blood flow passageways of the balloon, from one exterior face of the balloon to another exterior face. The saline solution continues to circulate around the blood flow passageways inside the balloon, to cool the blood, eventually exiting the balloon through a return lumen of the catheter.

Claims

1. A cooling apparatus for selective organ hypothermia, comprising:

a flexible catheter;

an inflatable balloon attached near a distal end of said catheter;

at least one blood flow passageway formed through the interior of said balloon, said at least one blood flow passageway extending from a proximal blood flow port in a proximal exterior face of said balloon to a distal blood flow port in a distal exterior face of said balloon;

a cooling fluid supply lumen formed in said catheter;

a cooling fluid supply port in said catheter, connecting said cooling fluid supply lumen to the interior of said balloon;

a cooling fluid return lumen formed in said catheter; and

a cooling fluid return port in said catheter, connecting the interior of said balloon to said cooling fluid return lumen;

wherein said at least one blood flow passageway is formed from a metallized polymer film.

2. A cooling apparatus as recited in claim 1, wherein said balloon is inflatable to a substantially cylindrical shape.

3. A cooling apparatus as recited in claim 1, wherein said at least one blood flow passageway assumes a substantially tubular shape upon inflation of said balloon.

4. A cooling apparatus as recited in claim 1, further comprising a guidewire lumen formed in said catheter.

5. A cooling apparatus as recited in claim 1, further comprising a plurality of blood flow passageways formed through the interior of said balloon, each said blood flow passageway extending from a proximal blood flow port in a proximal exterior face of said balloon to a distal blood flow port in a distal exterior face of aid balloon.

6. A cooling apparatus as recited in claim 1, wherein said at least one blood flow passageway is formed from a polymer film having metal layers formed on both interior and exterior surfaces.

7. A cooling apparatus as recited in claim 1, wherein said at least one blood flow passageway is formed from a polymer film loaded with metal particles.

8. A cooling apparatus for selective organ hypothermia, comprising:

a flexible catheter;

an inflatable balloon attached near a distal end of said catheter, said balloon being inflatable to a substantially cylindrical shape;

a plurality of blood flow passageways formed through the interior of said balloon, each said blood flow passageway extending from a proximal blood flow port in a proximal exterior face of said balloon to a distal blood flow port in a distal exterior face of said balloon, each said blood flow passageway being shaped to assume a substantially tubular shape upon inflation of said balloon, each said blood flow passageway being formed of a material having high thermal conductivity;

a cooling fluid supply lumen formed in said catheter;

a cooling fluid supply port in said catheter, connecting said cooling fluid supply lumen to the interior of said balloon;

a cooling fluid return lumen formed in said catheter; and

a cooling fluid return port in said catheter, connecting the interior of said balloon to said cooling fluid return lumen;

wherein each said blood flow passageway is formed from a metallized polymer film.

9. A cooling apparatus as recited in claim 8, wherein each said blood flow passageway is formed from a polymer film having metal layers formed on both interior and exterior surfaces.

10. A cooling apparatus as recited in claim 8, further comprising a guidewire lumen formed in said catheter.

11. A cooling apparatus as recited in claim 8, wherein each said blood flow passageway is formed from a polymer film loaded with metal particles.