Method of localizing an object in a turbid medium

• US 6,327,489 B1
• Filed: 02/22/2000
• Issued: 12/04/2001
• Est. Priority Date: 06/25/1998
• Status: Expired due to Term

• Current Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Original Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Inventors: Hoogenraad, Johannes H., ʼT Hooft, Gert W.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/486,158
• Time in Patent Office: 651 Days
• Field of Search: 600/473, 600/475-479, 600/310, 600/407, 356/300, 356/337, 356/338, 356/343, 356/446, 250/330, 250/338.1, 250/340, 250/341.1, 250/358.1, 382/128
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

The invention relates to a method of localizing an object in a turbid medium. After measurement of the intensities for a plurality of light paths between the light sources and the detectors, the measured intensities are normalized. Subsequently, an image of the interior of the turbid medium is reconstructed on the basis of the measured intensities. In order to counteract artefacts in the reconstructed image, the combination includes a weighting factor which reduces the effect exerted on the reconstructed image by the measured intensities with a high noise factor in comparison with the effect exerted thereon by the measured intensities with a low noise factor.

Claims

1. A method of localizing an object in a turbid medium comprising:

irradiating the turbid medium with light,

measuring intensities of a part of the light transported through the turbid medium along a plurality of light paths from a source point where the light enters the turbid medium to a measuring point where the light leaves the turbid medium, and

reconstructing an image of the interior of the turbid medium from a combination of measured intensities, wherein a weighting factor is applied to the combination of measured intensities which reduces an effect exerted on the reconstructed image by the measured intensities with a high noise factor relative to the effect exerted thereon by the measured intensities with a low noise factor,

wherein, for a light source and a measuring position at which intensities are measured, the method further comprises;

determining an estimated intensity from a transformation of a predetermined first image,

determining a difference between the measured intensities and the estimated intensity, and

determining a next image from the first image, a convergence factor and a back-transformation of the difference, the convergence factor being chosen depending on the weighting factor.

2. A method as claimed in claim 1, in which the transformation contains a product of a sensitivity matrix and the first image.

3. A method as claimed in claim 1, in which the back-transformation contains a product of an estimate of an inverse sensitivity matrix and the difference between the measured intensities and the calculated intensities.

4. A method of localizing an object in a turbid medium comprising:

irradiating the turbid medium with light,

measuring intensities of a part of the light transported through the turbid medium along a plurality of light paths from a source point where the light enters the turbid medium to a measuring point where the light leaves the turbid medium, and

reconstructing an image of the interior of the turbid medium from a combination of measured intensities, wherein a weighting factor is applied to the combination of measured intensities which reduces an effect exerted on the reconstructed image by the measured intensities with a high noise factor relative to the effect exerted thereon by the measured intensities with a low noise factor,

wherein the method further comprises;

determining variations of attenuation coefficients of the light paths from the measured intensities, and

determining a variation of an attenuation coefficient of a volume element of the turbid medium by means of a back-transformation which contains a weighted mean value of an estimate of an inverse sensitivity matrix with the variations determined for the attenuation coefficients of the light paths, the effect of the noise factor on the reconstruction being determined by the product of the weighting factor and the elements of the estimate of the inverse sensitivity matrix.

5. A method of localizing an object in a turbid medium comprising:

irradiating the turbid medium with light,

measuring intensities of a part of the light transported through the turbid medium along a plurality of light paths from a source point where the light enters the turbid medium to a measuring point where the light leaves the turbid medium, and

reconstructing an image of the interior of the turbid medium from a combination of measured intensities, wherein a weighting factor is applied to the combination of measured intensities which reduces an effect exerted on the reconstructed image by the measured intensities with a high noise factor relative to the effect exerted thereon by the measured intensities with a low noise factor,

wherein the method further comprises correcting the measured intensities by way of a normalized intensity which is determined by a combination of the measured intensity associated with a light path and a measured reference intensity associated with the light path in a reference medium.

6. A method of localizing an object in a turbid medium comprising:

irradiating the turbid medium with light,

measuring intensities of a part of the light transported through the turbid medium along a plurality of light paths from a source point where the light enters the turbid medium to a measuring point where the light leaves the turbid medium, and

reconstructing an image of the interior of the turbid medium from a combination of measured intensities, wherein a weighting factor is applied to the combination of measured intensities which reduces an effect exerted on the reconstructed image by the measured intensities with a high noise factor relative to the effect exerted thereon by the measured intensities with a low noise factor,

wherein the weighting factor is dependent on a reciprocal value of a noise factor,

wherein the method further comprises determining the noise factor by a combination of noise of the measurement, the measured intensity of the measurement, the noise of the reference intensity and the measured reference intensity.