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Very large scale immobilized polymer synthesis

  • US 6,329,143 B1
  • Filed: 08/04/1998
  • Issued: 12/11/2001
  • Est. Priority Date: 06/07/1989
  • Status: Expired due to Fees
First Claim
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1. A method of synthesizing a plurality of different polymers on a surface of a substrate, comprising:

  • (a) providing a substrate having a surface bearing multiple copies of a protective group removable on exposure to an electric field or electric current;

    (b) applying the electric field or electric current to the substrate to remove a protective group from a first known location on the surface of the substrate;

    c) exposing the surface of the substrate to a first protected monomer bearing a protective group removable on exposure to an electric field or electric current, whereby the protected monomer attaches to the first known location;

    (d) applying the electric field or electric current to the substrate to remove a protective group from a second known location on the surface of the substrate;

    (e) exposing the surface of the substrate to a second protective monomer bearing a protective group removable on exposure to an electric field or electric current, whereby the second protected monomer attached to the second known location;

    (f) repeating (b)-(e) while controlling the known locations on the surface of the substrate to synthesize a plurality of different polymers at known locations on the surface of a substrate.

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