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Spectrophotometric method and apparatus for blood typing

  • US 6,330,058 B1
  • Filed: 04/13/2000
  • Issued: 12/11/2001
  • Est. Priority Date: 04/14/1999
  • Status: Expired due to Term
First Claim
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1. A method for determining a type of a blood sample comprising the steps of:

  • collecting a reference optical density spectrum of a first subsample of a blood sample over a predetermined wavelength range generally in the ultraviolet-visible portion of the electromagnetic spectrum;

    mixing a second subsample of the blood sample with an antibody corresponding to a known blood type;

    collecting an antibody-treated optical density spectrum of the antibody-blood sample mixture over the predetermined wavelength range; and

    calculating a numerical indicator of agglutination by;

    calculating a first slope of the reference optical density spectrum and a second slope of the antibody-treated optical density spectrum over at least a portion of the predetermined wavelength range; and

    dividing the first slope by the second slope to yield a numerical indicator of agglutination;

    determine the blood type by comparing the numerical indicator of agglutination to a predetermined empirical value.

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