Using a multi-electrode probe in creating an electrophysiological profile during stereotactic neurosurgery

• US 6,330,466 B1
• Filed: 02/23/1999
• Issued: 12/11/2001
• Est. Priority Date: 02/23/1998
• Status: Expired due to Fees

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Hofmann, Ulrich G., Kewley, David T., Thompson, John H.
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US09/256,685
• Time in Patent Office: 1,022 Days
• Field of Search: 600/378, 600/544, 607/116, 607/139, 606/130
• US Class Current: 600/378
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/294 for nerve conduction study [NCS]
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis

Abstract

A multi-electrode probe is used to create an electrophysiological depth profile during stereotactic neurosurgery. A surgeon uses CT or MRI images to identify the general location of a target site in the brain and then inserts the multi-electrode probe into this area. Each electrode on the probe produces a signal that indicates the level of activity in a nearby neuron or cluster of neurons. A processor converts these signals into an electrophysiological depth profile indicating the level of activity detected by each of the electrodes. The surgeon identifies the precise location of the target site by watching the display to determine which electrode or group of electrodes detects the highest level of neuronal activity as the stimulus is provided.

Claims

1. A method of using a multi-electrode probe during stereotactic neurosurgery, the method comprising:

inserting a multi-electrode probe into an area of a brain that includes a target site to be treated, where the probe includes multiple electrodes on a plurality of shafts that produce output signals corresponding to neuronal activity at multiple sites in the brain; and

generating audible output based on the electrode output signals to provide an indication of a level of concurrent neuronal activity at each of the multiple sites in the brain, wherein each electrode'"'"'s output is mapped to a unique audible output.

2. The method of claim 1, further comprising generating from the electrode output signals graphical output that provides a depth profile indicating the level of concurrent neuronal activity at various depths in the brain.

3. The method of claim 2, wherein the graphical output provides an indication of spike rate for individual neurons at the multiple sites.

4. The method of claim 2, wherein the graphical output includes a visual indication of the level of neuronal activity at each of the multiple sites.

5. The method of claim 2 wherein the graphical output is presented in a user interface.

6. The method of claim 1, further comprising providing a stimulus directed to neurons at the target site to increase the level of neuronal activity at the target site.

7. The method of claim 1, further comprising selecting a probe that is tailored for use in the identified area of the brain.

8. The method of claim 1 further comprising, prior to inserting the multi-electrode probe, identifying the area of the brain that includes the target site to be treated.

9. The method of claim 1 wherein the output signals produced by the electrodes include information corresponding to different depth and width locations in the brain.

10. A multi-electrode probe system for use during stereotactic neurosurgery, the system comprising:

a multi-electrode probe adapted to be inserted into an area of a brain that includes a target site to be treated through stereotactic neurosurgery, where the probe includes multiple electrodes on a plurality of shafts that produce output signals corresponding to neuronal activity at multiple sites in the brain;

a processor that receives the output signals from the electrodes and derives a level of neuronal activity that occurs at each of the multiple sites; and

an output device that produces audible output based on the electrode output signals to provide an indication of the level of concurrent neuronal activity at each of the multiple sites in the brain, wherein each electrode'"'"'s output is mapped to a unique audible output.

11. The system of claim 10, further comprising a user interface that provides a depth profile indicating the level of concurrent neuronal activity at various depths in the brain.

12. The system of claim 11, wherein the user interface includes a visual display of the level of neuronal activity detected by each of the electrodes at multiple time slots.

13. The system of claim 12, wherein the visual display provides a color coded indicator of the level of neuronal activity.

14. The system of claim 10, wherein the probe is tailored for use in the identified area of the brain.

15. The system of claim 10, wherein the probe includes micromachined silicon electrodes.

16. The system of claim 10 wherein the output signals produced by the electrodes include information corresponding to different depth and width locations in the brain.

17. A method of using a multi-electrode probe during stereotactic neurosurgery, the method comprising:

producing a plurality of electrode output signals corresponding to neuronal activity at a plurality of sites in a brain by inserting a multi-electrode probe into an area of the brain; and

providing an audible indication of a level of concurrent neuronal activity at the plurality of sites by generating a unique audible output for each electrode based on the produced electrode output signals.

18. The method of claim 17 wherein the electrode output signals include information corresponding to different depth and width locations in the brain.

19. The method of claim 17 further comprising generating from the electrode output signals graphical output that provides a depth profile indicating the level of concurrent neuronal activity at various depths in the brain.

20. The method of claim 17 wherein the graphical output provides an indication of spike rate for individual neurons at the plurality of sites.

21. The method of claim 17 wherein the graphical output includes a visual indication of the level of neuronal activity at each of the plurality of sites.

22. The method of claim 17 further comprising providing a stimulus directed to neurons at the target site to increase the level of neuronal activity at the target site.

23. The method of claim 17 further comprising selecting a probe that is tailored for use in the identified area of the brain.