Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness

• US 6,330,469 B1
• Filed: 09/25/2000
• Issued: 12/11/2001
• Est. Priority Date: 03/17/1998
• Status: Expired due to Term

• Current Assignee: University of Virginia Patent Foundation (University of Virginia)
• Original Assignee: University of Virginia Patent Foundation (University of Virginia)
• Inventors: Moorman, J. Randall, Griffin, M. Pamela
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/668,309
• Time in Patent Office: 442 Days
• Field of Search: 600/515, 128/920
• US Class Current: 600/515
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/344 Foetal cardiography
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient'"'"'s RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.

Claims

1. An apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant comprising:

(a) a monitoring device, continuously monitoring heart rate variability in the premature newborn infant; and

(b) a microprocessor, identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness.

2. The apparatus of claim 1, wherein the microprocessor performs the step of generating a normalized data set of RR intervals.

3. The apparatus of claim 2, wherein the microprocessor calculates one or more of the third and higher moments of the data set and identifies the characteristic abnormality based on the one or more moments.

4. The apparatus of claim 3, wherein the microprocessor calculates the skewness of the data set and identifies the characteristic abnormality based on the skewness.

5. The apparatus of claim 3, wherein the microprocessor calculates the kurtosis of the data set and identifies the characteristic abnormality based on the kurtosis.

6. The apparatus of claim 2, wherein the microprocessor calculates one or more percentile values of the data set and identifies the characteristic abnormality based on the one or more percentile values.

7. The apparatus of claim 6, wherein the microprocessor calculates the 10th percentile value of the data set and identifies the characteristic abnormality based on the 10th percentile value.

8. An apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient comprising (1) a monitoring device, continuously monitoring the patient'"'"'s RR intervals, and (2) a microprocessor, said microprocessor performing steps comprising:

(a) generating a normalized data set of the RR intervals;

(b) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set;

(c) identifying an abnormal heart rate variability based on one or more of the moments and the percentile values.

9. The apparatus of claim 8, wherein the microprocessor calculates the third moment of the data set.

10. The apparatus of claim 8, wherein the microprocessor calculates the fourth moment of the data set.

11. The apparatus of claim 8, wherein the microprocessor calculates the 10th percentile of the data set.