Method for localizing electrical activity in the body

• US 6,330,470 B1
• Filed: 12/17/1999
• Issued: 12/11/2001
• Est. Priority Date: 12/17/1999
• Status: Expired due to Term

• Current Assignee: Philips North America LLC (Koninklijke Philips N.V.)
• Original Assignee: Electrical Geodesics, Inc. (Koninklijke Philips N.V.)
• Inventors: Ferree, Thomas C., Ericksen, K. Jeffrey, Tucker, Don M.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US09/466,583
• Time in Patent Office: 725 Days
• Field of Search: 600/544, 600/545, 600/546, 600/547
• US Class Current: 600/544
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]

Abstract

A method for localizing electrical activity in the body. A plurality of electrical devices apply a predetermined current (or voltage) to the surface of the body, and sense voltage (or current). The same electrical devices employed to sense voltage (or current) from sources of electrical activity within the body are also employed to sense voltage (or current) that results from the application of current (or voltage) by the other electrical devices. The voltages (or currents) sensed are used to characterize impedance within the body as well as to localize sources of the electrical activity.

Claims

1. A method for localizing a source of electrical activity within a mass of body tissue, comprising:

applying a predetermined electrical stimulus to a portion of the surface of the body tissue at a first location;

measuring an actual complementary response to said electrical stimulus at the surface of the body tissue at a second location spaced from said first location;

removing said predetermined electrical stimulus from said first location; and

measuring an actual complementary response to the source of electrical activity at the surface of the body tissue at substantially said second location.

2. The method of claim 1, further comprising estimating the conductivity of the mass of body tissue as a function of position therein by assuming a conductivity, calculating a complementary response to said electrical stimulus at said second location, comparing the calculated complementary response with the actual complementary response to said electrical stimulus to determine an error, and adjusting the assumed conductivity until the error is reduced to a predetermined acceptable amount.

3. The method of claim 1, further comprising estimating the strength and location of the source as a function of position in the mass of body tissue, calculating a complementary response to the source at said second location, comparing the calculated complementary response to the source with the actual complementary response to the source to determine an error, and adjusting the strength and location of the source until the error is reduced to a predetermined acceptable amount.

4. The method of claim 1, wherein said steps of measuring an actual complementary response to said electrical stimulus and measuring an actual complementary response to the source of electrical activity are performed at substantially the same time.

5. The method of claim 1, wherein said steps of applying said predetermined electrical stimulus at said first location, measuring said actual complementary response to said electrical stimulus at said second location, and measuring said actual complementary response to the source of electrical activity at substantially said second location are performed first to refine the location of the source to a sub-portion of the body, the method further comprising applying another predetermined electrical stimulus to a portion of the surface of the body tissue at a third location corresponding particularly to said sub-portion, measuring another actual complementary response to said other electrical stimulus at the surface of the body tissue at a fourth location also corresponding particularly to said sub-portion and spaced from said third location, removing said other predetermined electrical stimulus from said third location, and measuring another actual complementary response to the source of electrical activity at the surface of the body tissue at substantially said fourth location.

6. The method of claim 1, further comprising providing a carrier including two electrical devices, wherein a first of the electrical devices is adapted to carry out said step of applying said electrical stimulus and a second of the electrical devices is adapted to carry out both said steps of measuring said actual complementary response to said electrical stimulus and measuring said actual complementary response to the source of electrical activity.

7. The method of claim 6, wherein said carrier includes at least two additional electrical devices, wherein two of said at least two additional electrical devices and said first electrical device are arranged as vertices of a substantially equilateral triangle.

8. The method of claim 6, wherein said carrier includes at least two additional electrical devices, wherein two of said at least two additional electrical devices and said second electrical device are arranged as vertices of a substantially equilateral triangle.