Sensors for detecting analytes in fluids
First Claim
1. A method for identifying a chemical analyte, wherein said chemical analyte is a biomolecule, using a sensor array, said method comprising:
- (a) providing a sensor array, wherein each sensor comprises a conductive region and a nonconductive organic polymer region;
(b) contacting said biomolecule with said sensor array to produce a response; and
(c) analyzing said response thereby identifying said biomolecule.
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Abstract
Chemical sensors for detecting analytes in fluids comprise first and second conductive elements (e.g., electrical leads) electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive elements. The resistor comprises a plurality of alternating nonconductive regions (comprising a nonconductive organic polymer) and conductive regions (comprising a conductive material) transverse to the electrical path. The resistor provides a difference in resistance between the conductive elements when contacted with a fluid comprising a chemical analyte at a first concentration, than when contacted with a fluid comprising the chemical analyte at a second different concentration. Arrays of such sensors are constructed with at least two sensors having different chemically sensitive resistors providing dissimilar such differences in resistance. Variability in chemical sensitivity from sensor to sensor is provided by qualitatively or quantitatively varying the composition of the conductive and/or nonconductive regions. An electronic nose for detecting an analyte in a fluid may be constructed by using such arrays in conjunction with an electrical measuring device electrically connected to the conductive elements of each sensor.
246 Citations
23 Claims
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1. A method for identifying a chemical analyte, wherein said chemical analyte is a biomolecule, using a sensor array, said method comprising:
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(a) providing a sensor array, wherein each sensor comprises a conductive region and a nonconductive organic polymer region;
(b) contacting said biomolecule with said sensor array to produce a response; and
(c) analyzing said response thereby identifying said biomolecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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- 12. A sensor array for identification of a chemical analyte, wherein said analyte is a biomolecule, and wherein each sensor in said array comprises a conductive region and a nonconductive organic polymer region.
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22. A method for detecting the presence or level of a chemical analyte, wherein said analyte is a biomolecule, in a sample using a sensor array, said method comprising:
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(a) providing a sensor array, wherein each sensor comprises a conductive region and a nonconductive organic polymer region;
(b) contacting said sample with said sensor array to produce a response; and
(c) analyzing said response thereby detecting the presence and level of said biomolecule present in said sample. - View Dependent Claims (23)
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Specification