Optical sensors and multisensor arrays containing thin film electroluminescent devices
First Claim
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1. An optical sensor for detecting an analyte of interest in a sample, said optical sensor comprising;
- a sensing layer containing an indicator agent which can react optically with said analyte, a thin film electroluminescent device comprising a luminescent layer which emits light of a predetermined wavelength, wherein said luminescent layer is optically coupled to said sensing layer, wherein said indicator agent absorbs light energy of said predetermined wavelength and in the presence of at least one analyte of interest generates an optical response which is optically detectable and recognizable as indicating the presence of the analyte of interest, and wherein said thin film electroluminescent device comprises an organic electroluminescent material.
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Abstract
Optical sensor, probe and array devices for detecting chemical biological, and physical analytes. The devices include an analyte-sensitive layer optically coupled to a thin film electroluminescent layer which activates the analyte-sensitive layer to provide an optical response. The optical response varies depending upon the presence of an analyte and is detected by a photodetector and analyzed to determine the properties of the analyte.
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Citations
90 Claims
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1. An optical sensor for detecting an analyte of interest in a sample, said optical sensor comprising;
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a sensing layer containing an indicator agent which can react optically with said analyte, a thin film electroluminescent device comprising a luminescent layer which emits light of a predetermined wavelength, wherein said luminescent layer is optically coupled to said sensing layer, wherein said indicator agent absorbs light energy of said predetermined wavelength and in the presence of at least one analyte of interest generates an optical response which is optically detectable and recognizable as indicating the presence of the analyte of interest, and wherein said thin film electroluminescent device comprises an organic electroluminescent material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. An optical sensor array for detecting at least one analyte of interest in a fluid sample, said optical sensor array comprising:
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a plurality of sensing units at least some of which differ in their chemical formulations and their optical characteristics, which react optically differently with an individual analyte of interest, each of said sensing units of said array including;
a sensing layer containing an indicator agent, a thin film electroluminescent device having a luminescent layer which emits light of a predetermined wavelength, wherein said indicator agent absorbs light energy of said predetermined wavelength and in the presence of at least one analyte of interest generates an optical response which is detectable and recognizable as showing the presence of the analyte of interest, and wherein said thin film electroluminescent device comprises an organic electroluminescent material. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A kit comprising a plurality of optical sensors for detecting the presence of one or more analytes of interest in a sample, each sensor comprising:
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an anode, a hole transporting layer, an electron transporting layer, and a cathode, wherein said cathode and anode are capable of activating the emission of electroluminescence of a predetermined wavelength from either said hole transporting layer or said electron transporting layer;
a sensing layer optically coupled to said electroluminescent hole or electron transporting layer, wherein said sensing layer contains an indicator agent that absorbs light of said predetermined wavelength and generates an optical response that is dependent upon the absence or presence of said analyte; and
a detector for detecting the optical response from said sensing layer. - View Dependent Claims (43, 44, 45, 46, 47)
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48. An optical method for detecting an analyte of interest in a fluid sample, said method comprising:
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providing an optical sensing unit containing a sensing layer, and a thin film electroluminescent device wherein said sensing layer can absorb light of a predetermined wavelength and provide an optical response specific to the presence of an individual analyte of interest;
introducing a sample to contact said sensing layer;
activating said thin film electroluminescent device to emit light energy of said predetermined wavelength to said sensing layer;
optically detecting said optical response of said sensing layer;
evaluating said response to determine the presence or concentration of at least one analyte of interest in the sample; and
wherein said thin film electroluminescent device comprises an organic electroluminescent material. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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68. An optical sensor for detecting an analyte of interest in a sample, said optical sensor comprising;
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a sensing layer containing an indicator agent which can react optically with said analyte, a thin film electroluminescent device comprising a luminescent layer which emits light of a predetermined wavelength, wherein said luminescent layer is optically coupled to said sensing layer, wherein said indicator agent absorbs light energy of said predetermined wavelength and in the presence of at least one analyte of interest generates an optical response which is optically detectable and recognizable as indicating the presence of the analyte of interest, and wherein said thin film electroluminescent device comprises a first and a second hole transporting layer. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79)
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80. A layered device for detecting an analyte, comprising:
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a first layer comprising an indicating agent, said indicating agent having the capability of producing an optically detectable reaction in the presence of said analyte;
a second layer optically coupled to said first layer and comprising an organic material able to generate a light of a predetermined wavelength, wherein said light of a predetermined wavelength enables the optically detectable reaction of said indicating agent of said first layer; and
a third layer optically coupled to said first layer and comprising a photodetector, wherein said third layer is on the opposite side of said second layer from said first layer. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
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Specification