Method for treating diseased or damaged organs
First Claim
1. A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
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Accused Products
Abstract
This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient'"'"'s living cells.
334 Citations
12 Claims
- 1. A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
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6. A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in the patient with a tubular prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host'"'"'s cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises (a) a first layer that provides a smooth flow surface, wherein said first layer is derived from acid-extracted fibrillar or non-fibrillar collagen;
- and (b) a second layer that provides structural stability, wherein said second layer is derived from the tunica submucosa of the small intestine of a mammal.
- View Dependent Claims (7)
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8. A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host'"'"'s cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, has a thickness of between about 50 microns to about 150 microns, and is pliable, semi-permeable, and suturable.
- 9. A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular, collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host'"'"'s cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, and is pliable, semi-permeable, and suturable, and wherein said prosthesis has a diameter selected from the group consisting of less than 6 mm, between 6 to 12 mm, and greater than 12 mm.
Specification