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Melt-extrusion multiparticulates

  • US 6,335,033 B2
  • Filed: 07/22/1999
  • Issued: 01/01/2002
  • Est. Priority Date: 11/04/1994
  • Status: Expired due to Term
First Claim
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1. A unit dose sustained-release oral dosage form comprising a plurality of extruded particles, each of said particles comprising:

  • an opioid analgesic dispersed in a matrix comprising one or more hydrophobic materials selected from the group consisting of acrylic polymers and alkylcelluloses;

    said particles being non-spheroidal and having a size from about 0.1 mm to about 12 mm and a diameter from about 0.1 mm to about 5 mm, said unit dose providing a release of said opioid analgesic over at least about 6 hours, said particles being formed by mixing the opioid analgesic and the one or more hydrophobic materials in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

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