Extracorporeal circulation apparatus for selective cooling method

• US 6,336,910 B1
• Filed: 11/09/1998
• Issued: 01/08/2002
• Est. Priority Date: 04/26/1996
• Status: Expired due to Term

• Current Assignee: Tomio Ohta
• Original Assignee: Tomio Ohta
• Inventors: Ohta, Tomio, Kobayashi, Takuichi
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/187,986
• Time in Patent Office: 1,156 Days
• Field of Search: 604/4-6, 604/4.01, 604/5.01, 604/6-1-, 604/6.11, 604/6.13, 604/6-5-, 422/44-46, 210/739, 210/742, 210/767, 210/85, 210/88, 128/905, 128/DIG.3, 128/203-6-2
• US Class Current: 604/6.13
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: Y10S 128/03 Heart-lung

Abstract

An extracorporeal circulation apparatus capable of maintaining hypothermia for a prolonged period when used in the selective cooling method.

The extracorporeal circulation apparatus used in the selective cooling method includes (1) a diluent supply unit for cooling a diluent and metering the diluent into a blood vessel; (2) a blood concentration unit for metering a diluted blood out from a blood vessel and concentrating the diluted blood thus drawn out by filtering the diluted blood; and (3) a blood supply unit for heating the concentrated blood and metering the concentrated blood into a blood vessel, wherein a flow rate of the injected diluent flow rate, Vd and a flow rate of a filtrate, Vb are so controlled that a relationship 0.1 Vd≦Vb≦Vd is maintained.

Claims

1. An extracorporeal circulation apparatus for selectively cooling a body part of a mammal, said apparatus comprising:

a diluent supply unit for cooling a diluent and metering the cooled diluent into a blood vessel of a body part of a mammal such that blood of the body part of the mammal becomes diluted and the body part of the mammal becomes cooled, wherein said diluent supply unit includes

(i) a fluid supply pump to discharge the diluent into the blood vessel of the mammal,

(ii) a heat exchanger to cool the diluent before the diluent is discharged into the blood vessel of the mammal,

(iii) a container to supply the diluent to said fluid supply pump,

(iv) a catheter to supply the diluent, after the diluent has been discharged from said fluid supply pump and after the diluent has been cooled by said heat exchanger, into the blood vessel of the body part of the mammal,

(v) a flow meter to determine the flow rate of the diluent discharged from said fluid supply pump,

(vi) a thermometer to determine the temperature of the diluent after the diluent has been cooled by said heat exchanger and before the diluent is supplied into the blood vessel of the body part of the mammal, and

(vii) a drip chamber to remove air bubbles from the diluent before the diluent is supplied into the blood vessel of the body part of the mammal;

a blood concentration unit for metering the diluted blood from a blood vessel of the mammal and for concentrating the metered diluted blood to form concentrated blood; and

a blood supply unit for heating the concentrated blood and metering the heated concentrated blood into a blood vessel of the mammal.

2. The extracorporeal circulation apparatus according to claim 1, wherein said blood concentration unit includes a drawing-out/fluid supply pump to meter the diluted blood from a blood vessel of the mammal, and a blood concentration device to concentrate the diluted blood.

3. The extracorporeal circulation apparatus according to claim 2, wherein said blood supply unit includes a heat exchanger to heat the concentrated blood prior to metering the concentrated blood into a blood vessel of the mammal.

4. The extracorporeal circulation apparatus according to claim 3, and further comprising a control device to control said fluid supply pump and said drawing-out/fluid supply pump such that the flow rate of the diluent supplied into the blood vessel of the mammal and the flow rate of blood metered from the mammal can be controlled.

5. The extracorporeal circulation apparatus according to claim 2, wherein said blood concentration unit further includes a filtrate pump connected to said blood concentration device to adjust the pressure within said blood concentration device, and further comprising a control device to control said fluid supply pump, said drawing-out/fluid supply pump and said filtrate pump such that the flow rate of the diluent supplied into the blood vessel of the mammal, the flow rate of blood metered from the mammal and a filtrate flow rate can be controlled.

6. The extracorporeal circulation apparatus according to claim 1, wherein said blood supply unit includes a heat exchanger to heat the concentrated blood prior to metering the concentrated blood into a blood vessel of the mammal.

7. The extracorporeal circulation apparatus according to claim 6, wherein said blood supply unit further includes a catheter to meter the heated concentrated blood into a blood vessel of the mammal.

8. The extracorporeal circulation apparatus according to claim 7, wherein said blood supply unit further includes a drip chamber to remove air bubbles from the concentrated blood before the heated concentrated blood is metered into a blood vessel of the mammal.

9. The extracorporeal circulation apparatus according to claim 1, wherein said diluent supply unit is operable to cool the diluent to a temperature within the range of from 25°

C. to 3°

C.

10. The extracorporeal circulation apparatus according to claim 1, wherein said diluent supply unit is operable to maintain a flow rate of the cooled diluent being metered into the blood vessel of the body part of the mammal within the range of from 100 ml/min to 600 ml/min.

11. The extracorporeal circulation apparatus according to claim 1, wherein said blood concentration unit includes a filtration element having a filtrate flow rate within the range of from 30 ml/min to 200 ml/min.

12. The extracorporeal circulation apparatus according to claim 1, wherein said blood concentration unit is operable to concentrate the diluted blood to achieve a hematocrit value that is at least 80% of a hematocrit value of the blood before dilution of the blood.

13. The extracorporeal circulation apparatus according to claim 1, and further comprising an injection/dehydration controlling mechanism.

14. The extracorporeal circulation apparatus according to claim 1, wherein said blood supply unit includes a heat exchanger.

15. The extracorporeal circulation apparatus according to claim 1, wherein said heat exchanger is operable to cool the diluent to a temperature within the range of from 25°

C. to 3°

C.

16. The extracorporeal circulation apparatus according to claim 1, wherein said fluid supply pump is operable to maintain a flow rate of the cooled diluent being metered into the blood vessel of the mammal within the range of from 100 ml/min to 600 ml/min.

17. An extracorporeal circulation apparatus for selectively cooling a body part of a mammal, said apparatus comprising:

a diluent supply unit for cooling a diluent and metering the cooled diluent into a blood vessel of a body part of a mammal such that blood of the body part of the mammal becomes diluted and the body part of the mammal becomes cooled;

a blood concentration unit for metering the diluted blood from a blood vessel of the mammal and for concentrating the metered diluted blood to form concentrated blood, wherein said blood concentration unit includes

(i) a drawing-out/fluid supply pump for metering the diluted blood from the mammal,

(ii) a blood concentration device to concentrate the diluted blood,

(iii) a catheter to supply the metered diluted blood from a blood vessel of the mammal to said drawing-out/fluid supply pump,

(iv) an anticoagulant supply unit to supply an anticoagulant to the diluted blood after the diluted blood has been metered from a blood vessel of the mammal, and

(v) a drip chamber to remove air bubbles from the diluted blood after the diluted blood has been metered from a blood vessel of the mammal but before the diluted blood is supplied to said blood concentration device; and

a blood supply unit for heating the concentrated blood and metering the heated concentrated blood into a blood vessel of the mammal.

18. The extracorporeal circulation apparatus according to claim 17, wherein said blood concentration unit includes a drawing-out/fluid supply pump to meter the diluted blood from a blood vessel of the mammal, and a blood concentration device to concentrate the diluted blood.

19. The extracorporeal circulation apparatus according to claim 18, wherein said blood supply unit includes a heat exchanger to heat the concentrated blood prior to metering the concentrated blood into a blood vessel of the mammal.

20. The extracorporeal circulation apparatus according to claim 19, and further comprising a control device to control said fluid supply pump and said drawing-out/fluid supply pump such that the flow rate of the diluent supplied into the blood vessel of the mammal and the flow rate of blood metered from the mammal can be controlled.

21. The extracorporeal circulation apparatus according to claim 18, wherein said blood concentration unit further includes a filtrate pump connected to said blood concentration device to adjust the pressure within said blood concentration device, and further comprising a control device to control said fluid supply pump, said drawing-out/fluid supply pump and said filtrate pump such that the flow rate of the diluent supplied into the blood vessel of the mammal, the flow rate of blood metered from the mammal and a filtrate flow rate can be controlled.

22. The extracorporeal circulation apparatus according to claim 17, wherein said blood supply unit includes a heat exchanger to heat the concentrated blood prior to metering the concentrated blood into a blood vessel of the mammal.

23. The extracorporeal circulation apparatus according to claim 22, wherein said blood supply unit further includes a catheter to meter the heated concentrated blood into a blood vessel of the mammal.

24. The extracorporeal circulation apparatus according to claim 23, wherein said blood supply unit further includes a drip chamber to remove air bubbles from the concentrated blood before the heated concentrated blood is metered into a blood vessel of the mammal.

25. The extracorporeal circulation apparatus according to claim 17, wherein said diluent supply unit is operable to cool the diluent to a temperature within the range of from 25°

C. to 3°

C.

26. The extracorporeal circulation apparatus according to claim 17, wherein said diluent supply unit is operable to maintain a flow rate of the cooled diluent being metered into the blood vessel of the body part of the mammal within the range of from 100 ml/min to 600 ml/min.

27. The extracorporeal circulation apparatus according to claim 17, wherein said blood concentration unit includes a filtration element having a filtrate flow rate within the range of from 30 ml/min to 200 ml/min.

28. The extracorporeal circulation apparatus according to claim 17, wherein said blood concentration unit is operable to concentrate the diluted blood to achieve a hematocrit value that is at least 80% of a hematocrit value of the blood before dilution of the blood.

29. The extracorporeal circulation apparatus according to claim 17, and further comprising an injection/dehydration controlling mechanism.

30. The extracorporeal circulation apparatus according to claim 17, wherein said blood supply unit includes a heat exchanger.

31. The extracorporeal circulation apparatus according to claim 17, wherein said blood concentration unit further includes a filtrate pump connected to said blood concentration device to adjust the pressure within said blood concentration device.