Antimicrobial caries-detecting composition

• US 6,337,357 B1
• Filed: 01/28/2000
• Issued: 01/08/2002
• Est. Priority Date: 02/24/1997
• Status: Expired due to Term

• Current Assignee: Kuraray Noritake Dental Inc. (Kuraray Company Limited)
• Original Assignee: Kuraray Company Limited
• Inventors: Hino, Kenichi, Fukunishi, Kyoko
• Primary Examiner(s): SZEKELY, PETER A
• Application Number:
  US09/493,153
• Time in Patent Office: 711 Days
• Field of Search: 424/49, 433/217.1, 427/2.13, 523/122, 523/105, 106/35
• US Class Current: 523/122
• CPC Class Codes: A61K 2800/43 Pigments; Dyes
• CPC Class Codes: A61K 49/006 Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/4926 having six membered rings
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

An antimicrobial caries-detecting composition, which comprises (i) water, a water-miscible solvent or a combination thereof, (ii) a dye capable of staining the caries-infected portions of teeth, and (iii) at least one antimicrobial agent.

Claims

1. An antimicrobial caries-detecting composition, which is a solution consisting of:

(i) a solvent which is water, a water-miscible organic solvent or a combination thereof, (ii) a dye dissolved in the solvent in a concentration of 0.1 to 2 wt % capable of selectively staining the caries-infected portion of teeth, and (iii) at least one antimicrobial agent dissolved in the solvent selected from the group consisting of cationic microbiocides, biguanide microbiocides and halogenated diphenyl ether microbiocides.

2. The antimicrobial caries-detecting composition according to claim 1, wherein said antimicrobial agent is at least one member selected from the group consisting of trichlosan, irgasan, chlorhexidine and cetylpyridinium hydrochloride.

3. The antimicrobial caries-detecting composition according to claim 1, wherein said antimicrobial agent is at least one member selected from the group consisting of thymol, clove oil, homosulfamine, nitrofurazone, sulfonamides, acridine dyes, formalin, alexidine, cetapron, and metafen.

4. The antimicrobial caries-detecting composition according to claim 1, wherein said dye concentration ranges from 0.1-1 wt %.

5. A The antimicrobial caries-detecting composition according to claim 1, wherein said dye is basic fuchsine, eosine, erythrosine, acidic fuchsine, safranine, rose bengale, acid red, fast acid magenta, CI5410, CI42053, CI 45170, gentian violet, sodium copper chlorophyll, laccaic acid, cochineal or shisonin, wherein the CI number is the color index number.

6. The antimicrobial caries-detecting composition according to claim 1, wherein said solvent is ethanol, ethylene glycol, n-propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, isobutyl alcohol, n-amyl alcohol, isoamyl alcohol, diethylene glycol, triethylene glycol, tetraethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monoacetate, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoacetate, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether or glycerin.