Predictive bolus tracking

• US 6,337,992 B1
• Filed: 07/29/1999
• Issued: 01/08/2002
• Est. Priority Date: 01/29/1997
• Status: Expired due to Fees

• Current Assignee: Philips Medical Systems Technologies Ltd. (Koninklijke Philips N.V.)
• Original Assignee: Philips Medical Systems Technologies Ltd. (Koninklijke Philips N.V.)
• Inventors: Gelman, Haim
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Lin, Jeoyuh
• Application Number:
  US09/355,698
• Time in Patent Office: 894 Days
• Field of Search: 128/899, 600/407, 600/425, 600/436, 600/431, 250/336.1, 364/413.15, 364/413.17, 364/413.18, 378/25, 378/10, 378/19, 378/17, 378/4, 378/8, 378/16, 378/98, 378/98.2, 378/98.9, 378/686, 378/151, 378/153, 378/21, 378/23
• US Class Current: 600/425
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents

Abstract

A method for determining a time for acquiring contrast-enhanced images from a CT scanner of a subject into whom a contrast medium has been injected, the method including:

identifying a region of interest in an initial CT image of the body of a subject;

defining an attenuation data segment corresponding to the region of interest by reprojecting the region of interest in the initial image;

receiving attenuation data within the segment from a subsequent scan of the patient; and

independently processing the attenuation data received within the segment to estimate an optimal time for performing a diagnostic scan of the body, without reconstructing all or a portion of the CT image.

Claims

1. A method for determining a time for acquiring contrast-enhanced images from a CT scanner of a subject into whom a contrast medium has been injected, the method comprising:

identifying a region of interest in an initial CT image of the body of a subject;

defining an attenuation data segment corresponding to a region of interest by reprojecting the region of interest in the initial image;

receiving attenuation data within the segment from a subsequent scan of the patient; and

independently processing the attenuation data received within the segment to estimate an optimal time for performing a diagnostic scan of the body, without reconstructing all or a portion of the CT image.

2. A method according to claim 1 and including receiving an indication of the time of injection of a bolus of contrast medium.

3. A method according to claim 1 and including, performing a diagnostic scan at the estimated optimal time.

4. A method according to claim 3, wherein performing the diagnostic scan comprises performing a helical scan.

5. A method according to claim 1, wherein defining the attenuation data segment comprises defining segments in multiple angular views, and wherein processing the attenuation data comprises combining the data from the multiple views to determine the optimal time for performing the diagnostic scan.

6. A method according to claim 1, wherein processing the attenuation data comprises predicting a future value of the attenuation within the segment, and using the predicted value to estimate the optimal time for performing the diagnostic scan.

16. A method according to claim 1, wherein receiving the attenuation data comprises receiving attenuation data from a continuous dynamic scan of the body.

7. A method for determining a time for acquiring contrast-enhanced images corresponding to a region of interest from a body of a subject into whom a contrast medium is injected, from a CT scanner, the method comprising:

receiving attenuation data within a segment from a scan of the subject using the scanner;

predicting a future value of the attenuation within the segment, based on the attenuation data received; and

estimating an optimal time for performing a diagnostic scan of the body, using the predicted value.

8. A method according to claim 7 and including receiving an indication of a time of injection of a bolus of contrast medium.

9. A method according to claim 7 and including performing a diagnostic scan of the subject at the estimated time.

10. A method according to claim 9, wherein performing the diagnostic scan comprises performing a helical scan.

11. A method according to claim 7, and comprising identifying the region of interest in an initial CT image of the body, wherein defining the attenuation data segment comprises reprojecting an initial image to define the segment.

12. A method according to claim 7, wherein predicting the future value of the attenuation comprises fitting the attenuation data received within the segment to a functional curve.

13. A method according to claim 7, wherein predicting the future value of the attenuation comprises predicting a time at which the attenuation will reach a desired value thereof.

14. A method according to claim 13, wherein estimating the optimal time for performing the scan comprises determining a scan period which includes the time at which the attenuation will reach the maximum value.

15. A method according to claim 7, wherein defining the attenuation data segment comprises defining two attenuation data segments, and wherein predicting the future value of the attenuation comprises determining a delay between an attenuation increase in a first one of the two segments and a corresponding attenuation increase in the second of the segments.

17. A method according to claim 7 wherein receiving the attenuation data comprises receiving the attenuation data from a continuous dynamic scan of the body.

18. A CT scanner including:

a scanning system capable of receiving attenuation data, constructing a CT image in response thereto and defining a region of interest on said image;

a signal interface capable of receiving signals representative of a time of injection of a bolus of contrast material and of producing a signal indicating when a diagnostic scan should be performed;

bolus time arrival apparatus, that defines an attenuation data segment corresponding to a region of interest by reproducing data in the region of interest in an initial image and including a processor that independently processes attenuation data received within the segment in subsequent scans to estimate an optimal time for performing a diagnostic scan of the body.

19. A scanner according to claim 18, wherein the bolus time arrival apparatus defines attenuation segments in multiple angular views, and the processor combines the data from the multiple views to estimate the optimal time for performing the diagnostic scan.

20. A scanner according to claim 18, wherein the processor predicting a future value of the attenuation within the segment, and uses the predicted value to determine the optimal time for performing the diagnostic scan.

21. A CT scanner including:

a scanning system capable of receiving attenuation data, constructing a CT image in response thereto; and

bolus time arrival apparatus, that receives attenuation data from a plurality sequential scans and which estimates an optimum future time for performing a diagnostic scan based on the sequential attenuation data, said estimated future time being estimated prior to said future time.

22. A scanner according to claim 21 wherein the scanning system is capable of identifying a region of interest in an initial CT image of the body, wherein the bolus time arrival apparatus defines attenuation data segment on which said bolus time arrival apparatus bases its estimate by utilizing attenuation data only in segments based on reprojection of the region of interest.

23. A scanner according to claim 21, wherein the bolus time arrival apparatus fits a function of the attenuation data to a functional curve.

24. A scanner according to claim 21 wherein bolus time arrival apparatus is capable of defining the estimated future time as a time at which the attenuation will reach a desired value thereof.

25. A scanner according to claim 21, wherein the scanner performs scans for a period starting said estimated future time and during a scan period which includes the time at which the attenuation will reach the maximum value.

26. A scanner according to claim 21 wherein the sequential attenuation data is received from a continuous dynamic scan of the body.

27. A scanner according to claim 26 wherein the scan is a helical scan.

28. A method for determining a time for acquiring contrast-enhanced images from a body of a subject into whom a contrast medium is injected, from a CT scanner, the method comprising:

receiving attenuation data from a scan of the subject using the scanner; and

estimating an optimal time for performing a diagnostic scan of the body, using the received attenuation data;

wherein estimating an optimal time includes;

predicting a future value of the attenuation, based on the attenuation data received; and

estimating the optimal time based on the predicted future value of attenuation.

29. A CT scanner including:

means for acquiring an initial CT image of the patient;

means for defining a region of interest in the initial CT image;

means for defining an attenuation data segment corresponding to the region of interest by reprojecting the region of interest in the initial image;

means for injecting a bolus of contrast medium into a patient;

means for performing subsequent scans of the patient after said injection;

means for receiving attenuation data within the segment from the subsequent scans;

means for independently processing the attenuation data received within the segment to determine an optimal time for performing a diagnostic scan of the body; and

means for performing a diagnostic scan of the patient responsive to the determination of the optimal time to acquire a contrast enhanced CT image.

30. CT imaging apparatus including means for determining the time of an optimal scan after injection of a contrast medium, comprising:

a CT scanner;

means for acquiring an initial CT image of the patient;

means for identifying a region of interest in the initial CT image;

means for receiving an indication of the time of injection of a bolus of contrast medium;

means for defining an attenuation data segment corresponding to the region of interest by reprojecting the region of interest in the initial image;

means for performing subsequent scans of the patient;

means for receiving attenuation data within the segment from the subsequent scans;

means for independently processing the attenuation data received within the segment to determine an optimal time for performing a diagnostic scan of the body; and

means for performing a diagnostic scan of the patient responsive to the determination of the optimal time to acquire a contrast enhanced CT image.

31. CT imaging apparatus, comprising:

means for performing a scan of a patient;

means for receiving attenuation data within a segment of the scan;

means for predicting a future value of attenuation within the segment, based on the attenuation data received;

means for determining an optimal time for performing a diagnostic scan of the body, using the predicted value; and

means for performing a diagnostic scan of the patient at the determined time.

32. A method for determining a time for acquiring contrast-enhanced images from a body of a subject into whom a contrast medium is injected, from a CT scanner, the method comprising:

receiving attenuation data from a scan of the subject using the scanner;

reconstructing an image of a portion of the subject from the attenuation data;

receiving additional attenuation data from a scan of the subject using the scanner; and

estimating an optimal time for performing a diagnostic scan of the body, using the received additional attenuation data, without reconstructing all or a portion of an image of the subject, responsive to the received additional data.