Lubricious coatings for medical devices
First Claim
1. A stable, lubricious, biocompatible coating composition comprising a coupling agent, a polyfunctional polymer and at least one biocompatible agent, wherein said coupling and said polyfunctional polymer are in a ratio ranging from 10:
- 1 to 0.1;
1, and wherein said coupling agent and said polymer chemically interact to form a three-dimensional crosslinking network which is capable of physically entrapping said biocompatible agent.
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Accused Products
Abstract
Biocompatible surfaces on medical devices, particularly those formed of synthetic materials, are produced by providing coating compounds having crosslinked regions capable of entrapping biocompatible molecules on the surfaces of medical devices in order to form a stable base layer. The crosslinked base layer is lubricious and is able to function as an entrapping or coupling site for additional biocompatible agents, which agents may be stably incorporated into its crosslinked lattice. Thus, the coatings of the present invention have enhanced lubricity and may also have antimicrobial, protein-repelling, and/or antithrombotic properties. The present invention thus discloses novel, stable, biocompatible coating compositions, devices coated with the compositions of the present invention, methods of making and applying such compounds, and methods of preparing and using devices and apparatus coated with such compositions.
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Citations
16 Claims
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1. A stable, lubricious, biocompatible coating composition comprising a coupling agent, a polyfunctional polymer and at least one biocompatible agent, wherein said coupling and said polyfunctional polymer are in a ratio ranging from 10:
- 1 to 0.1;
1, and wherein said coupling agent and said polymer chemically interact to form a three-dimensional crosslinking network which is capable of physically entrapping said biocompatible agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- 1 to 0.1;
Specification