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Rodent models of human amyloidoses

  • US 6,340,783 B1
  • Filed: 10/03/1996
  • Issued: 01/22/2002
  • Est. Priority Date: 09/23/1992
  • Status: Expired due to Term
First Claim
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1. A method for producing a rodent model of Alzheimer'"'"'s disease comprising a) infusing a proteoglycan, or fragments thereof, in combination with a beta-amyloid protein into brain tissue of a rodent, b) allowing sufficient time for the proteoglycan, or fragments thereof, and the beta-amyloid protein to be co-deposited in the brain tissue, and c) detecting the amyloid deposit in the brain tissue using standard staining techniques for fibrillar amyloid.

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