Compact assay system with digital information
First Claim
1. An assay method, comprising:
- providing a solid support with opposed sides, one of which is an informational surface, the solid support having one or more capture binding agents immobilized on one side, each capture binding agent having a binding specicificity for an analyte of interest;
contacting the capture binding agents with a liquid sample in which one or more analytes may be present;
separating the liquid sample from the solid support;
incubating the capture binding agents with a developing agent, the developing agent capable of binding with analyte when bound to the capture binding agent, the developing agent including an optical marker, wherein the optical marker generates an optical signal in proportion to bound analytes;
detecting the optical signal; and
, recording onto the informational surface on the other side of the solid support information concerning the optical signal.
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Accused Products
Abstract
A compact assay system having a solid support has at least one capture binding agent on the support surface. By applying a combination of different binding agents on the support surface, the present invention can conduct multiple chemical reactions on the support solid support to detect analytes of interest. The specific reagents, or capture binding agents, are preferably immobilized on the solid support by means of a computer controlled, miniaturized printing system. Specifically, the reagents can be applied onto the solid support using a commercial available printhead of an ink-jet printer. In addition, the support surface also includes areas adapted to be digitally readable by laser to store information concerning binding between capture agents and analytes.
94 Citations
4 Claims
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1. An assay method, comprising:
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providing a solid support with opposed sides, one of which is an informational surface, the solid support having one or more capture binding agents immobilized on one side, each capture binding agent having a binding specicificity for an analyte of interest;
contacting the capture binding agents with a liquid sample in which one or more analytes may be present;
separating the liquid sample from the solid support;
incubating the capture binding agents with a developing agent, the developing agent capable of binding with analyte when bound to the capture binding agent, the developing agent including an optical marker, wherein the optical marker generates an optical signal in proportion to bound analytes;
detecting the optical signal; and
,recording onto the informational surface on the other side of the solid support information concerning the optical signal. - View Dependent Claims (2, 3, 4)
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Specification