Polymer glucan ether derivatives, their manufacturing as well as their use

• US 6,342,486 B1
• Filed: 07/18/1997
• Issued: 01/29/2002
• Est. Priority Date: 07/19/1996
• Status: Expired due to Term

• Current Assignee: Mibelle AG Cosmetics
• Original Assignee: Mibelle AG Cosmetics
• Inventors: Suter, Franz, Zülli, Fred
• Primary Examiner(s): Gitomer, Ralph
• Assistant Examiner(s): Khare, Devesh
• Application Number:
  US08/896,926
• Time in Patent Office: 1,656 Days
• Field of Search: 514/54, 514/844, 514/860, 514/863, 514/864, 536/120, 536/123.12, 536/124
• US Class Current: 514/54
• CPC Class Codes: A61K 2800/21 Emulsions characterized by droplet sizes below 1 micron
• CPC Class Codes: A61K 31/716 Glucans
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/068 Microemulsions
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: C08B 37/0009 alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
• CPC Class Codes: C08B 37/0024 beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Abstract

A method for treatment of skin includes topical application of a composition containing a therapeutically effective amount of a 1,3-beta-glucan ether derivative. Such application effectively provides treatment and/or prophylaxis of various skin-related problems, such as neurodermatitis and psoriasis, and reduces the evidence of aging by minimizing wrinkles. In an advantageous embodiment, the glucan ether derivative is present in the composition in a range of concentration of about 0.002% to about 8% by weight. In another embodiment the glucan ether derivative is advantageously carboxymethyl glucan sodium salt.

Claims

1. A method of treating skin for prophylaxis and/or therapy of diseases and/or irritations induced by oxidative stress in the skin, comprising topically applying a composition to the skin, said composition containing as an active ingredient a therapeutically effective amount of at least one glucan ether derivative, said at least one glucan ether derivative comprising respective monomer units of a formula I and a formula II:

wherein the monomer units of the formula I are connected with the monomer units of the formula II by a 1,3-beta-glycosidic bond; and

in the monomer units of formula II, X is selected from the group consisting of —

CH₂—

COO—

Y, —

CH₂—

CH₂—

COO—

Y, CH(CH₃)—

COO—

Y, —

CH₂—

CH₂—

SO₃—

Y, and mixtures thereof, and Y is selected from the group consisting of hydrogen, an alkali-metal, an alkaline-earth metal and mixtures thereof; and

wherein said at least one glucan ether derivative comprises a combination of monomer units of formula I and formula II so that there is an average degree of substitution of 0.75±

0.1.

2. A method according to claim 1, wherein said therapeutically effective amount is a concentration in a range of about 0.002% to about 8% by weight.

3. A method according to claim 1, wherein said therapeutically effective amount is a concentration in a range of about 0.02% to about 4% by weight.

4. A method according to claim 1, wherein said at least one glucan ether derivative includes at least one monomer of the formula II in which X is —

CH₂—

COO—

Y and Y is Na.

5. A method according to claim 1, wherein said therapeutically effective amount is a concentration in a range of about 0.002% to about 8% by weight, said composition further including:

an alcohol in a range of about 0% to about 3% by weight;

an alkylenglycol in a range of about 0.5% to about 15% by weight;

a paraffin in a range of about 1% to about 3% by weight;

other additives in a range of about 5.5% to about 9.5% by weight; and

water in a range of about 75% to about 92.988% by weight.

6. A method according to claim 5, wherein said concentration is about 0.04% by weight.

7. A method according to claim 5, wherein said at least one glucan ether derivative is carboxymethyl glucan sodium salt, and said concentration is about 0.04% by weight.

8. A method according to claim 1, wherein said therapeutically effective amount is a concentration in a range of about 0.002% to about 1% by weight, said composition having a cream-like consistency and further comprising:

panthenol in a range of about 1% to about 3% by weight;

a fatty additive in a range of about 15% to about 28% by weight;

other additives in a range of about 0.05% to about 7% by weight; and

water in a range of about 61% to about 83.948% by weight.

9. A method according to claim 1, wherein said composition further comprises at least one phospholipid, at least one oil and water.

10. A method according to claim 1, wherein said composition is a nanoemulsion of at least one phospholipid and at least one oil, and of said at least one glucan ether derivative.

11. A method according to claim 1, wherein said therapeutically effective amount is a concentration in a range of about 0.05% to about 1% by weight, said composition further comprising:

an oil in a range of about 15% to about 25% by weight;

a phospholipid in a range of about 1% to about 5% by weight;

an alcohol in a range of about 0% to about 8% by weight

other additives in a range of about 8% to about 15% by weight; and

water in a range of about 46% to about 75.9% by weight.