Multifunction electrode for neural tissue stimulation

• US 6,343,226 B1
• Filed: 09/30/1999
• Issued: 01/29/2002
• Est. Priority Date: 06/25/1999
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Neurokinetic APS
• Inventors: Sunde, Niels, Sørensen, Jens Chr.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): RUDDY, DAVID M
• Application Number:
  US09/409,458
• Time in Patent Office: 852 Days
• Field of Search: 600/373, 600/378, 600/372, 600/590, 607/116-118, 606/129, 606/130
• US Class Current: 600/378
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence

Abstract

Techniques whereby electrical stimulation to treat symptoms from central and peripheral nervous system disorders such as those found in e.g. Parkinson'"'"'s disease, epilepsy, psychiatric illness and intractable pain, using a quadripolar deep brain stimulation electrode connected to an implantable pulse generator have been expanded. By an implantation of an electrode, it is important for the outcome to determine the optimal placement of the electrode. By the invention, an electrode device is provided allowing stimulation of a large volume of neural tissue in combination with simultaneous microelectrode recording. Other improvements involve a temporary electro-physiological microrecording microelectrode/stilette 1, a bent electrode tip, a split electrode tip or an asymmetrical electrical stimulation field. This technique allows for a less traumatic localisation of the optimal neural stimulation area by microelectrode recording in combination with the placement of the permanent deep brain stimulation electrode.

Claims

1. A multifunction electrode device for neural tissue stimulation, comprising an elongated flexible electrode body that comprises a head section that comprises a plurality of electrode conductors, and electrical connections associated with the electrode conductors embedded in the elongated body, further comprising a stilette disposed within the elongated body, said stilette comprising an insulating coating around an electrically conducting core and an exposed tip, said tip of the stilette being advanceable through a tip of the electrode body for the performance of electrode recordings, the head section of the elongated body comprising a tension bend.

2. A multifunction electrode device according to claim 1, wherein the stilette comprises tungsten.

3. A multifunction electrode device according to claim 1, wherein the stilette comprises an electrically isolated body of plastic polymer comprising an exposed tip, the exposed tip being 1 μ

m ore more in diameter.

4. A multifunction electrode device according to claim 1, wherein the stilette of the electrode device is in communication with a microdrive so as to enable intracellular and extracelluar electrophysiological recordings.

5. A multifunction electrode device according to claim 1, wherein the elongated electrode body is moveably disposed within an inflexible insertion tube for insertion of the electrode device to a determined implant position.

6. A multifunction electrode device according to claim 5, wherein the electrode device is rotatable within the insertion tube, and wherein the device further comprises indications means in communication with at least one of the electrode device and the insertion tube for registration of a relative angular position relative angular position of the electrode device and the insertion tube.

7. A multifunction electrode device according to claim 1, wherein the tension bend has a length of 2-50 mm and a bending angle between 1°

and 179°

.

8. A multifunction electrode device according to claim 7, wherein the tension bend comprises a string of inert plastic polymer denser on one of the concave and convex sides of the bend.

9. A multifunction electrode device according to claim 1, wherein the head section comprises two or more bendable electrode legs having tips, and wherein each tip of said bendable electrode leg comprises an electrode conductor.

10. A multifunction electrode device according to claim 9, further comprising a conductor just above a bifurcation of the electrode legs.

11. A multifunction electrode device according to claim 9, wherein each of the bendable legs comprises a string of inert plastic polymer denser on one of the concave and convex sides of the bendable legs.

12. A multifunction electrode device according to claim 9, wherein the electrode conductor comprises a hollow tip having a shape of one of the group consisting of conical and paraboidal, and wherein the outermost section of the stilette is provided with means for spreading said bendable legs as the stilette is advanced outwards.

13. A multifunction electrode device according to claim 1, wherein at least some of the electrode conductors are asymmetrically arranged on the head section of the electrode device.

14. A multifunction electrode device according to claim 1, wherein the electrode device is a quadripolar electrode device.

15. A multifunction electrode device according to claim 7, wherein the string of inert plastic polymer denser comprises at least one of the group consisting of silicon and resorbable biocomposite.

16. A multifunction electrode device according to claim 11, wherein the string of inert plastic polymer denser on the legs comprises at least one of the group consisting of silicone and resorbable biocomposite.

17. A multifunction electrode device according to claim 13, wherein at least some of the electrode conductors are arranged in a linear configuration on one side of the electrode body.

18. A permanent electrode implantation for neural tissue stimulation comprising an electrode device, the electrode device comprising an elongated flexible electrode body that comprises a head section that comprises a plurality of electrode conductors, and electrical connections associated with the electrode conductors embedded in the elongated body, further comprising a stilette disposed within the elongated body, said stilette comprising an insulating coating around an electrically conducting core and an exposed tip, said tip of the stilette being advanceable through a tip of the electrode body for the performance of electrode recordings, the head section of the elongated body comprising a tension bend, wherein the electrode conductors and the stilette are electrically connected to an implantable pulse generating device for generating an electrical stimulation field of the neural tissue at a point of implant.

19. A method of implantation of a multifunction electrode device for neural tissue stimulation, the electrode device comprising an elongated flexible electrode body that comprises a head section that comprises a plurality of electrode conductors, and electrical connections associated with the electrode conductors embedded in the elongated body, further comprising a stilette disposed within the elongated body, said stilette comprising an insulating coating around an electrically conducting core and an exposed tip, said tip of the stilette being advanceable through a tip of the electrode body for the performance of electrode recordings, the head section of the elongated body comprising a tension bend, the method comprising the steps of inserting the electrode device to determine a desired electrode target by performing electro-physiological recordings through the combined stilette and electrode, and permanently implanting the electrode device once the desired target is located.

20. A method according to claim 19, further comprising the step of introducing the electrode device through an insertion tube of a mandrin such that as the tip exits from the insertion tube it bends at a predetermined angle, and such that the bent tip is rotatable through 360 degrees by rotating the electrode body.

21. A method according to claim 19, further comprising the steps of determining an optimal permanent electrode placement for the electrode device by retracting the electrode device into the insertion tube of the mandrin, adjusting its angular position relative to the insertion tube by rotation and advancing the electrode device through the tube, repeatedly introducing the bending electrode tip throughout a section of a cylindrical volume of nervous tissue and examining a result thereof to determine an optimal permanent electrode placement.