Replenishable stent and delivery system

• US 6,344,028 B1
• Filed: 08/30/1999
• Issued: 02/05/2002
• Est. Priority Date: 06/30/1994
• Status: Expired due to Term

• Current Assignee: Boston Scientific Corporation
• Original Assignee: Boston Scientific Corporation
• Inventors: Barry, James
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US09/385,604
• Time in Patent Office: 890 Days
• Field of Search: 604/96.01, 604/500, 604/501, 604/508, 604/509, 604/511, 604/101-104, 604/507, 606/192-194
• US Class Current: 604/96.01
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1093 having particular tip characteristics
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

Apparatus and a method for treating an irregularity in a wall of a vessel of a patient defined by an irregular or afflicted wall portion with adjacent normal wall portions comprises a catheter having a distal end portion for being guided through the vessel to the site of the irregularity. A balloon associated with said distal end portion of the catheter for selective inflating to contact the walls of the vessel urges a stent carried by the distal end portion of the catheter in a constricted condition for passage through the vessel into an expanded form with the stent spanning the afflicted wall portion and contacting the adjacent wall portions. The catheter is formed with lumens for inflating the balloon, for receiving a guidewire for guiding the catheter through the vessel, and for connecting a port in the catheter proximate the afflicted wall portion to enable delivery of a therapeutic agent into the vessel to contact the stent and the irregular wall portion.

Claims

1. A system for the delivery of a therapeutic agent to a vessel of a patient comprising:

a catheter having a proximal end portion and a distal end portion;

an expansible balloon on said distal end portion;

a stent over said balloon; and

a membrane over said stent, wherein said membrane defines a replenishable reservoir of therapeutic agent.

2. The system of claim 1, wherein the therapeutic agent comprises cells.

3. The system of claim 2, wherein said cells comprise endothelial cells.

4. The system of claim 1, wherein the therapeutic agent comprises paclitaxel.

5. The system of claim 1, wherein the therapeutic agent comprises a gene construct.

6. The system of claim 1, wherein the therapeutic agent is selected from the group consisting of heparin, PPACK, iloprost, integrelin, chimeric antibodies, antisense oligonucleotides, angiopeptin, probucol, nitroglycerin, and papaverine.

7. The system of claim 1, wherein the therapeutic agent is attached to a material selected from the group consisting of albumin, cells, fibrin, proteins, platelets, polymers, liposomes, and red blood cells.

8. The system of claim 1, wherein said stent is a self-expanding stent.

9. The system of claim 1, wherein said membrane comprises a polymer.

10. The system of claim 9, wherein said polymer is a hydrophilic polymer.

11. The system of claim 9, wherein said polymer is a hydrophobic polymer.

12. The system of claim 1, wherein said balloon is a channeled balloon.

13. The system of claim 12, wherein the therapeutic agent is delivered though said balloon to contact membrane.

14. A system for the delivery of cells to a vessel of a patient comprising:

a catheter having a proximal end portion and a distal end portion;

a first lumen within said catheter and extending from said proximal end portion to said distal end portion;

wherein the cells are delivered to a vessel through said first lumen; and

an stent located at the distal end portion of said catheter.

15. The system of claim 14, wherein said cells comprise endothelial cells.

16. The system of claim 14 wherein said stent is a self expanding stent.

17. The system of claim 14 further comprising a membrane over said stent.

18. The system of claim 14 further comprising an expansible balloon on the distal end portion of said catheter.

19. The system of claim 18 wherein said stent is carried in a constricted condition on the balloon.

20. A system for the delivery of a therapeutic agent to a vessel of a patient comprising:

a catheter having a proximal end portion and a distal end portion;

an expansible balloon on said distal end portion;

a stent over said balloon; and

a membrane over said stent, wherein said membrane contains a therapeutic agent selected from the group consisting of heparin, PPACK, iloprost, integrelin, chimeric antibodies, antisense oligonucleotides, angiopeptin, probucol, nitroglycerin, and papaverine.