Transdermal absorption of active substances from subcooled melts
First Claim
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1. A method of releasing a pharmaceutical agent for effecting a topical or systemic effect in a patient from a transdermal therapeutic system having a layered structure and comprising at least one substance selected from the group of pharmaceutical agents producing a local or systemic effect and at least one auxiliary agent which increases the penetration of said pharmaceutical agents and has a melting point above room temperature, which comprises:
- a) in a first step preparing said transdermal therapeutic system by using an auxiliary agent which has been melted and afterwards allowed to form a subcooled melt by cooling it down to room temperature, and b) in a second step applying the transdermal therapeutic system as prepared in the first step on the skin of said patient.
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Abstract
A pharmaceutical product for the release of medicinal agents to the skin having absorption-increasing auxiliary agents is characterized in that the auxiliary material forms subcooled melts.
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6 Claims
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1. A method of releasing a pharmaceutical agent for effecting a topical or systemic effect in a patient from a transdermal therapeutic system having a layered structure and comprising at least one substance selected from the group of pharmaceutical agents producing a local or systemic effect and at least one auxiliary agent which increases the penetration of said pharmaceutical agents and has a melting point above room temperature, which comprises:
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a) in a first step preparing said transdermal therapeutic system by using an auxiliary agent which has been melted and afterwards allowed to form a subcooled melt by cooling it down to room temperature, and b) in a second step applying the transdermal therapeutic system as prepared in the first step on the skin of said patient. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification