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Methods of producing nucleic acid ligands

  • US 6,344,318 B1
  • Filed: 10/02/1998
  • Issued: 02/05/2002
  • Est. Priority Date: 06/11/1990
  • Status: Expired due to Fees
First Claim
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1. A method for preparing a modified nucleic acid ligand having a specific affinity for a given target comprising:

  • a) identifying a nucleic acid ligand to said target, wherein said nucleic acid ligand has specific affinity for said target;

    b) determining the structure of said nucleic acid ligand; and

    c) modifying said nucleic acid ligand, wherein said modifying comprises replacing one or more nucleotides with a modified monomer to produce said modified nucleic acid ligand, wherein said modified nucleic acid ligand mimics the structure of said nucleic acid ligand and wherein said modified nucleic acid ligand has a specific affinity to said target.

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