Enhanced high resolution breast imaging device and method utilizing non-ionizing radiation of narrow spectral bandwidth

• US 6,345,194 B1
• Filed: 03/21/2000
• Issued: 02/05/2002
• Est. Priority Date: 06/06/1995
• Status: Expired due to Fees

• Current Assignee: Nelson, Robert S., Reuven D. Zach
• Original Assignee: Nelson, Robert S., Reuven D. Zach
• Inventors: Nelson, Robert S., Zach, Reuven D.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/532,365
• Time in Patent Office: 686 Days
• Field of Search: 600/425, 600/473, 600/476, 250/340, 250/341.1, 250/360.1, 250/358.1, 250/338.1
• US Class Current: 600/425
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence

Abstract

The present invention provides a method and apparatus for high resolution breast imaging using collimated non-ionizing radiation in the near ultraviolet, visible, infrared and microwave regions (i.e. “light”) rather than ionizing x-radiation. The incident collimated light is transmitted through and backscattered out of a breast and loses intensity due to the properties of the breast materials in the beam path. Normal and diseased breast materials may exhibit comparatively distinct characteristics when exposed to different wavelengths of light and thereby be differentiated. Collimation can be used to control the level of scattered radiation which reaches the detector. Transmission and/or backscattered measurements can be acquired from a number of perspectives. Radiation coupling materials can be employed during image acquisition to enhance radiation coupling into and out of the breast as well as well as providing desirable absorption, scattering, heat removal, lubrication, and tissue compensation properties. The effects of the pattern of a structured collimator on image quality can be reduced by moving the structured (patterned) collimator in a reciprocating manner during image acquisition. Additional scatter reduction and/or improved sensitivity can be attained by compressing a region of the breast using contoured and/or flat compression plates of various sizes. An acoustic field can be introduced into a volume of breast tissue, altering its optical qualities. These changes can be recorded by intersecting an optical field with the acoustic field, providing spatial information and tissue characterization.

Claims

1. An apparatus for obtaining mammography images of a sub-portion of a human breast using non-ionizing radiation comprising:

a source of non-ionizing radiation of relatively narrow spectral bandwidth disposed such that the radiation will be incident on a sub-portion of the breast to be scanned,

a collimator disposed distal from said source to enable placement of the sub-portion of the breast to be scanned between said source and said collimator,

a radiation detector disposed so as to detect radiation having passed through said collimator, and

an optically transparent structure of suitable index of refraction for enabling compression of the sub-portion of the breast, the optically transparent structure including a breast compression surface configured to contact and compress the sub-portion of the breast, wherein the breast compression surface has a surface area less than 100 cm².

2. The apparatus of claim 1 including an optical coupling material of suitable index of refraction positioned adjacent the optically transparent structure to accomplish at least one of reducing the scattering and reflection of radiation;

lubricating the breast surface for moving a structure across the breast;

limiting heat buildup at the breast surface;

equalizing radiation path lengths through pores in the skin, depressions on the surface, or gaps between the rim of a breast and the optically transparent structure; and

interfacing a source or detector to the skin surface or the optically transparent structure.

3. The apparatus of claim 2 wherein the collimator comprises at least one of an air gap, fiber optics, amplified fiber optics, a mask, a focused lens, a waveguide, a focused array, a narrow spectral bandwidth filter, a light pipe, a mechanical aperture, a polarization filter, a reciprocating patterned collimator, and the optical coupling material.

4. The apparatus of claim 1 wherein the optically transparent structure comprises two plates of substantially the same size.

5. The apparatus of claim 1 wherein the optically transparent structure comprises two plates of different sizes.

6. The apparatus of claim 1 wherein the optically transparent structure comprises two plates of substantially the same size that can be moved in tandem along the portion of breast to be scanned during image acquisition.

7. The apparatus of claim 1 wherein the optically transparent structure comprises two plates of different sizes wherein at least one plate can be moved during image acquisition.

8. The apparatus of claim 1 wherein the optically transparent structure is contoured and provides at least one of gradual compression to the breast, a flat radiation entrance surface, and steep compression to the breast.

9. The apparatus of claim 1 wherein the source provides at least one of a coded waveform, a complex waveform, a modulated waveform, a continuous waveform, and a pulsed waveform.

10. A method for obtaining mammography images of a sub-portion of a human breast using non-ionizing radiation, comprising:

(1) selecting an optically transparent structure for compressing the breast, wherein the optically transparent structure is specifically selected having a small breast compression surface configured to compress only a sub-portion of the breast, wherein the volume of the sub-portion that is to be compressed has a volume substantially less than the volume of the remaining uncompressed portion of the breast;

(2) positioning the optically transparent structure proximate the breast;

(3) compressing the sub-portion of the breast with the optically transparent structure;

(4) irradiating the sub-portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth;

(5) allowing the radiation to transmit through the sub-portion of the breast;

(6) reducing the intensity of radiation scattered by the sub-portion of the breast by collimating the radiation with at least one of an air gap, a mask, fiber optics, amplified fiber optics, a focused lens, a light pipe, a waveguide, a focused array, a narrow spectral bandwidth filter, a mechanical aperture, a polarization filter, a reciprocating patterned collimator, and an optical coupling material;

(7) detecting the radiation after it has passed through the sub-portion of the breast and has been collimated; and

(8) using the detected radiation after it has passed through the sub-portion of the breast to form a mammography image of the portion of the breast to be scanned.

11. The method of claim 10 wherein step (4) of the method comprises irradiating the sub-portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth having at least one of a coded waveform, a complex waveform, a modulated waveform, a continuous waveform, and a pulsed waveform.

12. The method of claim 10 including the step of introducing an optical coupling material of suitable index of refraction between the optically transparent structure and the surface of the breast prior to irradiating the sub-portion of the breast with non-ionizing radiation of a relatively narrow spectral bandwidth.

13. The method of claim 10 wherein the optically transparent structure comprises two plates of substantially the same size including the additional step of moving the two plates of the optically transparent structure in tandem simultaneously with irradiating the sub-portion of the breast.

14. The method of claim 10 wherein the optically transparent structure comprises two plates of substantially different size, including the additional step of moving at least one plate of the optically transparent structure simultaneously with irradiating the portion of the breast to be scanned.

15. The method of claim 10 wherein the step of compressing the breast with the optically transparent structure provides at least one of gradual compression, a flat radiation entrance surface, and steep compression to the sub-portion of the breast.

16. The method of claim 10 wherein steps 1-8 are repeated for a plurality of sub-portions of the breast.

17. The method of claim 16 further including the step of combining the mammography image formed for each sub-portion of the breast scanned to form a complete image of the whole breast.