Methods and kits for locally administering an active agent to an interstitial space of a host
First Claim
1. A method of locally administrating an active agent to a host, said method comprising:
- retroinfusing said agent into a vascular vessel of said host under conditions sufficient to produce a disruption in said vessel and for said agent to enter an interstitial space of said host through said disruption so that said agent is locally administered to said host.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods are provided for locally administering an agent to a host. Specifically, the subject methods provide for the local administration of an agent to an interstitial space of a host. In the subject methods, an agent is retroinfused into a vessel of a host, typically a vein, under conditions sufficient for the agent to enter an interstitial space of the host proximal to the vessel location into which the agent is retroinfused. In practicing the subject methods, the agent is administered to the host in combination with the production of vascular stress at the site of administration, where the vascular tissue stress is sufficient to provide for transport of the agent from the vascular site of deposition into the target interstitial space. In a preferred embodiment, the agent is retroinfused at a pressure sufficient to provide for mechanical stress on the vessel proximal to the target interstitial space. Also provided are kits for use in practicing the subject methods. The subject invention finds use in the local administration of a variety of different agents for treatment of a variety of different disease or other conditions.
-
Citations
19 Claims
-
1. A method of locally administrating an active agent to a host, said method comprising:
retroinfusing said agent into a vascular vessel of said host under conditions sufficient to produce a disruption in said vessel and for said agent to enter an interstitial space of said host through said disruption so that said agent is locally administered to said host. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
8. A method of locally administering an active agent to a host, said method comprising:
retroinfusing said agent into a vein of said host under conditions sufficient to produce a disruption in said vessel and for said agent to enter an interstitial space of said host through said disruption so that said agent is locally administered to said host. - View Dependent Claims (9, 10, 11, 12, 13, 14)
-
15. A method of locally administering an active agent to a host, said method comprising:
-
retroinfusing said agent into a vein of said host with a catheter and at a pressure sufficient to produce a disruption on said vein such that said agent enters an interstitial space proximal to the vein through said disruption;
whereby said agent is locally administered to said host. - View Dependent Claims (16, 17, 18, 19)
-
Specification