Compounds and compositions for delivering active agents
First Claim
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1. A composition comprising:
- (A) at least one active agent; and
(B) a compound having the following formula or a salt thereof.
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Abstract
The present invention provides a compound having the formula
or a salt thereof which facilitates the delivery of active agents. Compositions and dosage unit forms comprising the compound of the present invention and at least one active agent, such as a peptide, mucopolysaccharide, carbohydrate, or a lipid, are also provided. Methods of administration and preparation of the compounds and compositions of the invention are provided as well.
207 Citations
27 Claims
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1. A composition comprising:
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(A) at least one active agent; and
(B) a compound having the following formula or a salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
(A) a composition as defined in claim 1; and
(B) (a) an excipient (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof.
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12. The dosage unit form as defined in claim 11, wherein said active agent is selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof.
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13. The dosage unit form as defined in claim 12, wherein said biologically active agent comprises at least one peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.
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14. The dosage unit form as defined in claim 13, wherein said biologically active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-1, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, parathyroid hormone, desferrioxamine, an anti-microbial agent, an anti-fungal agent, and any combination thereof.
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15. A dosage unit form as defined in claim 14, wherein said biologically active agent comprises an interferon, interleukin-II, insulin, heparin, low molecular weight heparin, calcitonin, oxytocin, vasopressin, vancomycin, DFO, parathyroid hormone, or a combination thereof.
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16. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises parathyroid hormone.
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17. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises recombinant human growth hormone.
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18. A dosage unit form as defined on claim 12, wherein said biologically active agent comprises interferon.
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19. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises heparin.
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20. A dosage unit form as defined in claim 12, wherein said biologically active agent comprises low molecular weight heparin.
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21. A dosage unit form as defined in claim 11, comprising a tablet, a capsule, or a liquid.
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22. A dosage unit form as defined in claim 21, wherein said dosing vehicle is selected from the group consisting of water, 1,2-propane diol, ethanol, and any combination thereof.
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23. A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in claim 2.
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24. A compound having the formula
or a salt thereof.
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26. A composition comprising:
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(A) at least one active agent; and
(B) a poly(amino acid) comprising a monomer having the formula or a salt thereof. - View Dependent Claims (27)
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Specification