High affinity TGfβ nucleic acid ligands and inhibitors
First Claim
Patent Images
1. A purified and isolated non-naturally occurring RNA ligand to transforming growth factor β
- 2 (TGFβ
2) wherein said ligand is selected from the group consisting of the sequences set forth in Tables 5, 7, 8, 11, 13, 14, 16-19, and FIG. 9 (SEQ ID NOS;
21-121 and 128-193).
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Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ2. Included in the invention are specific RNA ligands to TGFβ2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGFβ2 with its receptor.
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Citations
5 Claims
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1. A purified and isolated non-naturally occurring RNA ligand to transforming growth factor β
- 2 (TGFβ
2) wherein said ligand is selected from the group consisting of the sequences set forth in Tables 5, 7, 8, 11, 13, 14, 16-19, and FIG. 9 (SEQ ID NOS;
21-121 and 128-193). - View Dependent Claims (2, 3, 4, 5)
- 2 (TGFβ
Specification