Method of evaluating the efficacy of drug on brain nerve cells
First Claim
1. A method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of:
- a) measuring N-acetylaspartate (NAA) signal intensity using magnetic resonance spectroscopy (MRS) of the brain of the patient;
b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and
c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain;
whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.
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Abstract
The present invention relates to a method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of: a) measuring NAA signal intensity using MRS of the brain of the patient; b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain; whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.
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Citations
4 Claims
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1. A method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of:
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a) measuring N-acetylaspartate (NAA) signal intensity using magnetic resonance spectroscopy (MRS) of the brain of the patient;
b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and
c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain;
whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.- View Dependent Claims (2, 3, 4)
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Specification