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Method of evaluating the efficacy of drug on brain nerve cells

  • US 6,347,239 B1
  • Filed: 11/13/1998
  • Issued: 02/12/2002
  • Est. Priority Date: 03/13/1998
  • Status: Expired due to Term
First Claim
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1. A method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of:

  • a) measuring N-acetylaspartate (NAA) signal intensity using magnetic resonance spectroscopy (MRS) of the brain of the patient;

    b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and

    c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain;

    whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.

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