Electrotransport adhesive for iontophoresis device

• US 6,347,246 B1
• Filed: 02/03/2000
• Issued: 02/12/2002
• Est. Priority Date: 02/03/2000
• Status: Expired due to Term

• Current Assignee: Axelgaard Manufacturing Co. Ltd.
• Original Assignee: Axelgaard Manufacturing Co. Ltd.
• Inventors: Heard, George S., Shenkute, Solomon E., Perrault, James J.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/497,097
• Time in Patent Office: 740 Days
• Field of Search: 604/20, 604/501, 204/291, 252/500, 128/798, 128/802, 128/803, 424/484, 424/486, 514/944
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention provides an electrically conductive adhesive hydrogel comprising from about 15 to about 60%, by weight of a cationic polymer prepared by the polymerization of a monomer having the formula:

wherein m is an integer of from 1 to 3; R₁, R₂ and R₃ are selected from the group consisting of H and hydrocarbyl radicals having from 1 to 15 carbon atoms and X⁻ is an anion and from about 5 to less than about 40% water, by weight. This electrically conductive adhesive hydrogel is useful in the manufacture of medical devices, e.g. medical electrodes, and in particular, in iontophoretic medicament delivery devices wherein said polymer may function as a scavenger of hydroxyl ions generated during iontophoresis.

Claims

1. An electrically conductive adhesive hydrogel comprising from about 15 to about 60%, by weight of a cationic polymer prepared by the polymerization of a monomer having the formula:

wherein m is an integer of from 1 to 3;

R_{1, R2} and R₃ are selected from the group consisting of H and hydrocarbyl radicals having from 1 to 15 carbon atoms and X⁻

is an anion and from about 5 to less than about 40% water, by weight.

2. The hydrogel of claim 1 wherein the polymer has the formula

wherein m is an integer of from 1 to 3; R_{1, R2} and R₃ are selected from the group consisting of hydrogen and selected from the group consisting of H and hydrocarbyl radicals having from 1 to 15 carbon atoms, and n is a number greater than 1000.

3. The hydrogel of claim 2 wherein m is 2 and R₁ and R₂ and R₃ are selected from the group consisting of phenyl and CH₃.

4. The hydrogel of claim 2 wherein the monomer polymerized is acryloxyethyldimethylbenzyl ammonium chloride.

5. The hydrogel of claim 1 where X⁻

is a chloride or sulfate anion.

6. The hydrogel of claim 1 comprising from about 20 to about 50% by weight of said cross-linked cationic acrylate polymer.

7. The hydrogel of claim 1 comprising about from 25 to about 40% by weight of cross-linked cationic acrylate polymer.

8. The hydrogel of claim 1 further comprising up to about 10% by weight water.

11. A medical device comprising the adhesive hydrogel of claim 1.

13. The medical device of claim 11 further comprising a medicament.

14. The hydrogel of claim 1 further comprising a medicament.

15. An electrically powered iontophoretic medicament delivery device including a donor electrode assembly, a counter electrode assembly and a source of electrical power adapted to be electrically connect to the donor electrode assembly and the counter electrode assembly, the donor electrode assembly including:

(a) a medicament reservoir containing the hydrogel of claim 14, the medicament reservoir adapted to be placed in medicament transmitting relation with a body surface by adhering said medicament reservoir to said body surface by means of said hydrogel; and

(b) a donor electrode adapted to be electrically connected to the source of electrical power, the donor electrode being in electrical contact with the medicament reservoir.

16. The hydrogel of claim 2 further comprising from about 1 to about 40%, by weight of a primary amine as a proton or hydrogen ion scavenger.

17. The hydrogel of claim 16 wherein said primary amine is N, N, N′

, N′

-Tetrakis (2-hydroxypropyl) ethylene diamine.

18. The hydrogel of claim 17 comprising from about 6 to about 8% by weight, water.

9. An electrode comprising an electrically conductive adhesive hydrogel comprising from about 15 to about 60%, by weight of a cationic polymer prepared by the polymerization of a monomer having the formula:

wherein m is an integer of from 1 to 3;

R₁, R₂ and R₃ are selected from the group consisting of H and hydrocarbyl radicals having from 1 to 15 carbon atoms and X⁻

is an anion and from about 5 to less than about 40% water.

10. A medical device comprising the electrode of claim 9.

12. The medical device of claim 10 further comprising a medicament.

19. An electrically conductive adhesive hydrogel comprising from about 15 to about 60%, by weight of a cationic polymer prepared by the polymerization of a monomer having the formula:

wherein m is an integer of from 1 to 3;

R_{1, R2} and R₃ are selected from the group consisting of H and hydrocarbyl radicals having from 1 to 15 carbon atoms and X⁻

is an anion and water in an amount ranging from no more than sufficient to polymerize said monomer in a simple mix and cure process up to no more than 40%, by weight.