Bioactive shunt

• US 6,348,042 B1
• Filed: 02/02/1999
• Issued: 02/19/2002
• Est. Priority Date: 02/02/1999
• Status: Expired due to Term

• Current Assignee: Warren W. Lee Jr
• Original Assignee: Warren W. Lee Jr
• Inventors: Warren, W. Lee Jr.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/241,690
• Time in Patent Office: 1,113 Days
• Field of Search: 604/8-10, 604/264-266, 604/523, 604/6.16, 424/422-426, 424/484, 424/486, 424/400, 424/405, 424/487-491, 424/520, 424/529, 424/537, 424/570, 424/94-- 9, 424/94.6, 424/94-3-, 427/2.1, 427/2.24, 427/2.25, 427/2.28, 523/111-112, 523/105, 523/122, 523/200, 623/1-4-, 623/11, 623/12
• US Class Current: 604/8
• CPC Class Codes: A61K 38/465 acting on ester bonds (3.1), e.g. lipases, ribonucleases
• CPC Class Codes: A61K 38/482 Serine endopeptidases (3.4.21)
• CPC Class Codes: A61K 38/4826 Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 38/49 Urokinase; Tissue plasminogen activator
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Abstract

The present invention relates to a shunt, and a method for treating catheters, more particularly shunts, wherein the catheter is made of a biocompatible material and adapted at least for insertion into the brain of a living organism and enzymes are impregnated, either directly or through a matrix forming system, into the interior of the lumen of the catheter. The enzymes impregnated have at least one of the following characteristics: (1) they require a confirmational form and either completely or substantially lose their activity upon dislocation from the interior of the lumen; (2) they require the presence of co-factors for activation which co-factors are also present in the interior of the lumen but are not otherwise present in the biological system in sufficient quantity to excite activation of the impregnated enzymes.

Claims

1. A shunt, comprising:

an elongated tubular element made of biocompatible material and adapted at least for insertion into the brain of a living organism;

a surface coating applied solely to the interior lumen surface, said surface coating comprising a matrix-forming system; and

at least one enzyme impregnated in said coating, wherein said enzyme requires a specific physical configuration for activation wherein said configuration is lost upon dislocation of said enzyme from said coating.

2. The shunt of claim 1, further comprising:

an impregnated cofactor for said enzyme wherein said enzyme further requires said cofactor for activation.

3. The shunt of claim 1 or 2, wherein said matrix-forming system is a polymer.

4. The shunt of claim 1 or 2, wherein said matrix-forming system is a hydrogel.

6. The shunt of claim 1, 5 or 2, wherein said enzyme is a proteolytic enzyme from the group of lipases, urokinase, trypsin, collengenase.

7. The shunt of claim 6 wherein said matrix-forming system is a polymer.

8. The shunt of claim 1, 5 or 2, wherein said enzyme is a bacterial enzyme.

9. The shunt of claim 8, wherein said matrix-forming system is a polymer.

5. A shunt, comprising:

an elongated tubular element made of a biocompatible polymer and adapted at least for insertion into the brain of a living organism; and

at least one enzyme impregnated solely in the interior lumen surface in said biocompatible polymer, wherein said enzyme requires a specific physical configuration for activation wherein said configuration is lost upon dislocation of said enzyme from said biocompatible polymer.

10. A method for reducing the obstruction of a catheter lumen, comprising:

coating solely the interior surface of said catheter lumen with a matrix-forming system;

impregnating at least one enzyme in said matrix-forming system, wherein said enzyme requires a specific physical configuration for activation wherein said configuration is lost upon dislocation of said enzyme from said matrix-forming system.

11. A method of claim 10 further comprising:

impregnating a cofactor for said enzyme wherein said enzyme requires said co-factor for activation.

12. A method of claim 10, wherein said enzyme is a proteolytic enzyme from the group of lipases, urokinase, trypsin, collengenase.

13. A method of claim 10, wherein said enzyme is a bacterial enzyme.

14. A method of claim 10, wherein said matrix-forming system is a polymer.

15. A method of claims 10, 11, 12 or 13, wherein said matrix-forming system is a hydrogel.

16. A shunt, comprising:

an elongated tubular element made of a biocompatible polymer and adapted at least for insertion into the brain of a living organism;

at least one enzyme impregnated solely in the interior lumen surface in said biocompatible polymer, wherein said enzyme requires a specific physical configuration for activation wherein said configuration is lost upon dislocation of said enzyme from said biocompatible polymer; and

an impregnated cofactor for said enzyme wherein said enzyme further requires said cofactor for activation.

17. The shunt of claim 16 wherein said enzyme is a proteolytic enzyme from the group of lipases, urokinase, trypsin, collengenase.

19. The shunt of claims 16, 17 or 18 wherein said matrix-forming system is a polymer.

20. The shunt of claims 16, 17 or 18 wherein said matrix-forming system is a hydrogel.

18. The shunt of claim l6, wherein said enzyme is a bacterial enzyme.