Starting dialysate composition for use as an initial dialysate in hemo dialysis

• US 6,348,162 B1
• Filed: 04/03/2000
• Issued: 02/19/2002
• Est. Priority Date: 09/04/1992
• Status: Expired due to Term

• Current Assignee: Thermasolutions
• Original Assignee: Viacirq Incorporated
• Inventors: Ash, Stephen R.
• Primary Examiner(s): ANTHONY, JOSEPH DAVID
• Application Number:
  US09/541,956
• Time in Patent Office: 687 Days
• Field of Search: 252/184, 252/194, 210/502.1, 210/503, 210/504, 210/321.71, 210/648, 210/649, 210/646, 604/4, 604/5, 604/6
• US Class Current: 252/184
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1649 with pulsatile dialysis fluid flow
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3493 using treatment agents in suspension
• CPC Class Codes: A61M 1/3607 Regulation parameters
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/366 by liquid heat exchangers

Abstract

An apparatus for use in whole body hypothermia includes a dialyzer having a blood side and a dialysate side separated by one or more dialysis membranes. A blood pump associated with the a blood circuit established on the blood side circulates blood through the dialyzer at high rates advantageous for hyperthermia treatments. A bypass is included whereby circulated blood can bypass the dialyzer. The bypass aids in preventing blood-side tensioning of dialyzer membranes thereby allowing proper membrane movement to assist in mixing a sorbent suspension circulated on the dialysate side of the dialyzer. A sorbent suspension composition for use as a dialysate in hemodialysis, especially when performed in conjunction with whole body hyperthermia, includes water, a surface adsorptive agent such as charcoal, a cation exchanger, and precipitated calcium phosphate. The precipitated calcium phosphate serves as a reservoir for calcium and phosphate ions to assist in controlling patient blood chemistries.

Claims

1. A starting dialysate composition for use as an initial dialysate in hemodialysis, comprising:

a sorbent suspension including water, a particulate surface adsorptive agent, a particulate cation exchanger, and precipitated calcium phosphate.

2. The composition of claim 1 wherein the cation exchanger is loaded principally with calcium.

3. The composition of claim 1 wherein the surface adsorptive agent is charcoal.

4. The composition of claim 3 wherein the cation exchanger is loaded with calcium, potassium and magnesium ions.

5. The composition of claim 3 wherein the cation exchanger is a polymer resin.

6. The composition of claim 5 wherein the polymer resin is sodium polystyrene sulfinate.

7. The composition of claim 5 which further comprises a surface active agent and a flow inducing agent.

8. The composition of claim 7 wherein the flow inducing agent is a glycol derivative.

9. A composition comprising:

a sorbent suspension including water, a particulate surface adsorptive agent, a precipitated calcium phosphate located on the particulate surface adsorptive agent, and a particulate cation exchanger.