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Ibuprofen and narcotic analgesic compositions

  • US 6,348,216 B1
  • Filed: 06/10/1997
  • Issued: 02/19/2002
  • Est. Priority Date: 06/10/1996
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical tablet comprising a compressed composition substantially free of lactose and polyvinylpyrrolidone, said compressed composition comprising a granule comprised of:

  • a) ibuprofen;

    b) hydrocodone bitartrate;

    c) colloidal silicon dioxide;

    d) a filler selected from the group consisting of microcrystalline cellulose and powdered cellulose;

    e) a disintegrant; and

    a f) starch;

    wherein the granule is formed by a wet granulation process and said granule comprises the ibuprofen and the hydrocodone bitartrate in a single phase; and

    wherein the composition further comprises an extra granule material comprising a lubricant; and

    wherein the composition flows well, has good compression performance and can be compressed over a wider range of compression forces with no substantial change in the disintegration time of the tablet; and

    wherein said ibuprofen, said hydrocodone bitartrate, and said lubricant are present in said tablet in a single phase.

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