Formulations for the treatment of gastro-oesophageal reflux

• US 6,348,502 B1
• Filed: 04/04/2001
• Issued: 02/19/2002
• Est. Priority Date: 06/10/1998
• Status: Expired due to Fees

• Current Assignee: Reckitt Benckiser Healthcare UK Ltd (Reckitt Benckiser Group PLC)
• Original Assignee: Reckitt & Colman Products Limited (Reckitt Benckiser Group PLC)
• Inventors: Gardiner, Fiona Kate, Dettmar, Peter William, Jolliffe, Ian Gordon
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US09/719,129
• Time in Patent Office: 321 Days
• Field of Search: 514/627
• US Class Current: 514/627
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/357 having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• CPC Class Codes: A61K 31/4525 containing a five-membered ring with oxygen as a ring hetero atom
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/0065 Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
• CPC Class Codes: A61K 9/5036 Polysaccharides, e.g. gums, alginate; Cyclodextrin
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

Formulations for the treatment of gastro-oesophageal reflux diseases include a carrier vehicle and an active gastro-protective agent. The carrier vehicle is either capable of forming a floating barrier layer on contact with gastric acid or of forming a bioadhesive film before any contact with gastric acid, so as to protect gastric mucosa from irritation by the gastric acid. A preferred active ingredient is capsaicin. The carrier vehicle preferably contains alginate or cross-linked polyacrylic acid.

Claims

1. A pharmaceutical composition for the treatment of gastro-oesophageal reflux disease which comprises

(1) a carrier vehicle which is capable of producing a floating barrier layer on contact with gastric acid or which is capable of forming a bioadhesive film which binds to the oesophageal region, and

(2) at least one active ingredient selected from capsaicin ((E)-(N)-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide), zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone), curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), piperine (1-[5-1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine), resiniferatoxin (daphnetoxin 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-20-(4-hydroxy-3-methoxybenzene acetate), pharmaceutically acceptable derivatives and salts thereof.

2. A composition as claimed in claim 1, wherein, on contact with gastric acid, the carrier vehicle forms a floating barrier comprising a carbonated raft, mucoadhesive granules, an oil dispersion, or a wax dispersion.

3. A composition as claimed in claim 2, wherein the carrier vehicle includes an alginate.

4. A composition as claimed in claim 2, wherein the carrier vehicle includes cross-linked polyacrylic acid.

5. A composition as claimed in claim 2, wherein the active ingredient is capsaicin.

6. A composition as claimed in claim 2, wherein the active ingredient is resiniferatoxin.

7. A composition as claimed in claim 1 in which the carrier vehicle forms a bioadhesive film in the oesophagus prior to any contact with gastric acid.

8. A composition as claimed in claim 7, wherein the carrier vehicle includes an alginate.

9. A composition as claimed in claim 7, wherein the carrier vehicle includes cross-linked polyacrylic acid.

10. A composition as claimed in claim 7, wherein the active ingredient is capsaicin.

11. A composition as claimed in claim 7, wherein the active ingredient is resiniferatoxin.

12. A composition according to claim 1 in which the active ingredient comprises the crude extracts of capsicum, cayenne pepper, black pepper, paprika, mace, mustard, ginger, turmeric or papaya seed.

13. A composition according to claim 1 which is in unit dosage form and comprises from 0.001 to 40 mg of active ingredient.

14. A composition according to claim 13 in which the unit dosage form comprises from 0.025 to 2.5 mg of the active ingredient.

15. A composition as claimed in claim 14 in which the active ingredient is capsaicin.

16. A method for treating gastro-oesophageal reflux diseases which comprises administering to a person in need of such treatment a composition which comprises

(1) a carrier vehicle which is capable of producing a floating barrier layer on contact with gastric acid or which is capable of forming a bioadhesive film which binds to the oesophageal region, and

(2) at least one active ingredient selected from capsaicin ((E)-(N)-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide), zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone), curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), piperine (1-[5-1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine), resiniferatoxin (daphnetoxin 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-20-(4-hydroxy-3-methoxybenzene acetate), pharmaceutically acceptable derivatives and salts thereof.

17. A method as claimed in claim 16 in which the carrier vehicle includes an alginate.

18. A method as claimed in claim 16 in which the active ingredient is capsaicin.

19. A method as claimed in claim 16 in which the carrier vehicle forms, on contact with gastric acid, a floating barrier comprising a carbonated raft, mucoadhesive granules, an oily dispersion or a wax dispersion.

20. A method as claimed in claim 16 in which the carrier vehicle forms a bioadhesive film in the oesophagus prior to any contact with gastric acid.

21. In the preparation of medicaments for the treatment of gastric ulcers and/or gastritis, the improvement which comprises incorporating into said medicament a composition which comprises

(1) a carrier vehicle which is capable of producing a floating barrier layer on contact with gastric acid or which is capable of forming a bioadhesive film which binds to the oesophageal region, and

(2) at least one active ingredient selected from capsaicin ((E)-(N)-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide), zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone), curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), piperine (1-[5-1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine), resiniferatoxin (daphnetoxin 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-20-(4-hydroxy-3-methoxybenzene acetate), pharmaceutically acceptable derivatives and salts thereof.

22. The improvement as claimed in claim 21 in which the active ingredient is capsaicin.

23. The improvement as claimed in claim 21 in which the carrier vehicle comprises alginate.