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Formulations for the treatment of gastro-oesophageal reflux

  • US 6,348,502 B1
  • Filed: 04/04/2001
  • Issued: 02/19/2002
  • Est. Priority Date: 06/10/1998
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical composition for the treatment of gastro-oesophageal reflux disease which comprises(1) a carrier vehicle which is capable of producing a floating barrier layer on contact with gastric acid or which is capable of forming a bioadhesive film which binds to the oesophageal region, and (2) at least one active ingredient selected from capsaicin ((E)-(N)-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide), zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone), curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), piperine (1-[5-1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine), resiniferatoxin (daphnetoxin 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-20-(4-hydroxy-3-methoxybenzene acetate), pharmaceutically acceptable derivatives and salts thereof.

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