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Integrated optic waveguide immunosensor

  • US 6,350,413 B1
  • Filed: 10/05/1999
  • Issued: 02/26/2002
  • Est. Priority Date: 02/23/1995
  • Status: Expired due to Term
First Claim
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1. A method of performing a specific binding assay comprising:

  • providing a biosensor including a step gradient waveguide including a planar substrate formed of a first optical material of refractive index n1 and a waveguide film formed of a second optical material having a refractive index n2, which is greater than n1, said waveguide film comprising a plurality of separate, disconnected waveguide film strips on the planar surface;

    immobilizing at least one specific binding molecule onto said plurality of discrete waveguide film strips, said at least one specific binding molecule configured to bind an analyte with specificity;

    providing a light source positioned to direct light into the step gradient waveguide;

    providing a light detection means to detect light from a region proximate the step gradient waveguide;

    contacting said at least one specific binding molecule with a sample containing said analyte; and

    operating said light detection means to detect light emanating from said step gradient waveguide indicative of the presence of said analyte within said sample.

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