Electrospraying for mass fabrication of chips and libraries
First Claim
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1. A method for fabricating a deposit of a non-volatile biologically functional and/or biologically active substance on a substrate, comprising:
- electrospraying a solution of said non-volatile biologically functional and/or biologically active substance under a voltage effective to atomize said solution without destroying the functional properties of the non-volatile biologically functional and/or biologically active substance; and
depositing the electrosprayed substance in the form of dry deposit on contact with a surface of the substrate as the biologically functional and/or biologically active substance.
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Abstract
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to determine the interaction of the deposited non-volatile substances to other substances. Also included in this method is the mass fabrication on a single chip of an array of single and multicomponent microsamples.
103 Citations
43 Claims
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1. A method for fabricating a deposit of a non-volatile biologically functional and/or biologically active substance on a substrate, comprising:
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electrospraying a solution of said non-volatile biologically functional and/or biologically active substance under a voltage effective to atomize said solution without destroying the functional properties of the non-volatile biologically functional and/or biologically active substance; and
depositing the electrosprayed substance in the form of dry deposit on contact with a surface of the substrate as the biologically functional and/or biologically active substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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25. The method in accordance with 1, wherein the electrosprayed solution further comprises a stabilizer.
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43. A method for fabricating a deposit of a non-volatile biologically functional and/or biologically active substance on a substrate, comprising:
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electrospraying a solution of said non-volatile biologically functional and/or biologically active substance under conditions which prevent corona discharge with partial or complete evaporation of solvent; and
depositing the electrosprayed biologically functional and/or biologically active substance on a surface of the substrate as a dry charged residue or as a highly concentrated solution.
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Specification