Redrawn capillary imaging reservoir
First Claim
1. A method of making an array of biological samples comprising the steps of:
- a) providing a device having a plurality of open ended channels extending from an input face to an output face wherein at least along a length, each channel decreases approximately equally in diameter, cross sectional area, and wall thickness;
b) filling a plurality of said channels with a liquid that is capable of hardening under proper conditions, whereby said liquid contains a biological material;
c) allowing said liquid to harden; and
d) slicing a section of said device such that said sliced section becomes the array.
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Accused Products
Abstract
Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure. The liquid within the channels is either printed directly from the tool onto a substrate or transferred to a substrate by a typographical pin plate. In another embodiment, the device may be used in transferring sample between multiwell plates of different well density.
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Citations
13 Claims
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1. A method of making an array of biological samples comprising the steps of:
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a) providing a device having a plurality of open ended channels extending from an input face to an output face wherein at least along a length, each channel decreases approximately equally in diameter, cross sectional area, and wall thickness;
b) filling a plurality of said channels with a liquid that is capable of hardening under proper conditions, whereby said liquid contains a biological material;
c) allowing said liquid to harden; and
d) slicing a section of said device such that said sliced section becomes the array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification