Method and a device for electro microsurgery in a physiological liquid environment

• US 6,352,535 B1
• Filed: 04/08/1999
• Issued: 03/05/2002
• Est. Priority Date: 09/25/1997
• Status: Expired due to Fees

• Current Assignee: Nanoptics, Incorporated
• Original Assignee: Nanoptics, Incorporated
• Inventors: Palanker, Daniel, Lewis, Aaron, Turovets, Igor
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US09/269,408
• Time in Patent Office: 1,062 Days
• Field of Search: 606/41, 606/42, 606/45-50, 606/169, 606/2.5, 601/3, 601/4, 607/100-105, 604/114
• US Class Current: 606/45
• CPC Class Codes: A61B 17/22022 using electric discharge
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/26 for producing a shock wave, e.g. laser lithotripsy
• CPC Class Codes: A61B 2017/00154 pulsed
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00601 Cutting
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/1425 Needle
• CPC Class Codes: A61B 2018/1472 for use with liquid electrolyte, e.g. virtual electrodes
• CPC Class Codes: Y10S 977/856 including etching/cutting

Abstract

A method and device for electrical emulation of pulsed laser is disclosed. The device utilizes high voltage electrical discharges of sub-microsecond duration in a liquid medium to produce cavitation bubbles of sub-millimeter size for use in high speed precision cutting. Such bubbles are produced by a micro-electrode (1.6) having a central wire having a diameter of 1 microns to 100 microns embedded in an insulator. A coaxial electrode (1.9) surrounds the insulator, and may be spaced from the outer surface of the insulator to provide a path for removing tissue.

Claims

1. A device consisting of:

a microelectrode formed of a single metal wire inside an insulator, said insulator having a diameter of less than about 1 mm and said wiring having an exit diameter of less than 100 microns;

a second electrode surrounding said insulator; and

a high voltage pulse generator capable of producing a voltage in the range of 100 V to 10 kV connected between said wire and said second electrode for generating a pulse having a duration in the range of 0.030 to 3 μ

s that causes generation of a submicrosecond duration discharge in a conducting medium between said wire and said second electrode with pulse energies in the range of 1-1000 μ

J.

2. The device of claim 1, wherein said wire has an exit diameter of between 1 and 100 microns.

3. The device of claim 2, wherein said insulator is tapered.

4. The device of claim 3, wherein said insulator is pulled glass.

5. The device of claim 1, wherein said wire has an exit diameter of between 5 and 40 micrometers.

6. The device of claim 1, wherein said second electrode is a coating on said insulator.

7. The device of claim 1, wherein said second electrode has an outside diameter of less than 1 mm.

8. The device of claim 1, wherein said discharge has a duration sufficient to produce a cavitation bubble having a diameter of between 0.4 and 0.5 mm.

9. A device consisting of:

a microelectrode formed of a single metal wire inside an insulator, said wire having an exit diameter of less than 100 microns;

an electrode surrounding said metal wire and said insulator, said electrode having a diameter between 0.9 and 1.0 mm; and

a high voltage pulse generator capable of producing a voltage in the range of 100 V to 10 kV connected to said wire for generating pulses having durations of between 30 ns and 3 μ

s to cause generation of submicrosecond duration sparks in a conductive medium between said wire and said electrode, the generated pulses having pulse energies in the range of 1-1000 μ

J.

10. The device of claim 9 wherein said sparks produce cavitation bubbles having diameters of between 0.4 and 0.5 mm.

11. The device of claim 9, wherein said electrode comprises a conductive coating on said insulator.

12. The device of claim 9, further including a gap between said insulator and said electrode.

13. The device of claim 9, wherein said insulator is pulled glass to produce a tapered insulator and an exit wire diameter of between 1 and 100 microns, and wherein said electrode is a conductive coating on said insulator.

14. A device comprising:

a microelectrode comprising a glass microcapillary having a metal wire inside the glass, the microcapillary being tapered to a point and coated with metal to form a concentric metal needle, said metal wire having an exit diameter in the range of 1-100 microns; and

a high voltage pulse generator connected to said wire to generate a submicrosecond duration discharge in a conducting liquid containing medium with pulse energies in the range of 1-1000 μ

J to produce a cavitation bubble, said discharge having a duration sufficiently short to produce a bubble having a diameter no greater than 0.5 mm in said conducting medium with characteristics that emulate the action of pulsed lasers in said conducting medium.

17. A device as recited in claim 14, 15 or 16, further including a second electrode.

18. A device as recited in claim 14, 15 or 16, further including a second electrode, and a gap between said second electrode and said microelectrode for lifting treated tissue by suction of said medium through this gap, and the evacuation of gas bubbles and tissue debris that result from tissue cutting.

19. A device as in claim 14, 15 or 16, further including means for attachment to a catheter for the simultaneous delivery of drugs to a treated area.

20. A device as in claim 14, 15 or 16, in which said microelectrode is composed of multiple metal wires inside said insulator.

21. A device as in claim 14, 15 or 16, in which said microelectrode includes a tip which is bent at an angle with the axes of the microelectrode that can vary from a few degrees to as much as 180 degrees with respect to the microelectrode axis.

22. A device as in claim 14, 15 or 16, in which a tip of the microelectrode is bent in a manner that causes a resulting action at the surface of said medium to occur at an angle with the axis of said microelectrode, and wherein the axis of the microelectrode defines a cantilever that is flexible enough to bend and measure surface forces so that such a device can cause fine alterations on a surface with resolutions that can be sub-micrometer to nanometer in dimension.

23. A device as in claim 14, 15 or 16, in which the microelectrode has a flat tip or an angled tip.

24. A device as in claim 14, 15 or 16, in which the microelectrode has a round tip.

25. A device as in claim 14, 15 or 16, comprising an array of parallel microelectrodes generating a parallel array of cavitation bubbles.

15. A device comprising:

a microelectrode comprising a glass microcapillary having a metal wire inside the glass, the microcapillary being tapered to a point and coated with metal to form a concentric metal needle, said metal wire having an exit diameter of less than 100 microns; and

a high voltage pulse generator connected to said wire to generate an electrical discharge having a duration in the range of 0.030 to 3.0 microsecond in a conducting liquid containing medium with pulse energies in the range of 1-1000 μ

J to produce in said conducting medium submillimeter-sized cavitation bubbles with characteristics that emulate the action of pulsed lasers.

16. A device comprising:

a microelectrode comprising a glass microcapillary having a metal wire inside the glass, the microcapillary being tapered to a point and coated with metal to form a concentric metal needle, said metal wire having an exit diameter in a range of 1-100 microns; and

a high voltage pulse generator connected to said metal wire and having a pulse shaped to generate at the metal wire exit a submicrosecond duration electrical discharge through a gas layer in a conducting liquid containing environment with a pulse energy in the range of 1-1000 μ

J to produce cavitation bubble generation in said conducting medium in a manner that produces cavitation bubbles which collapse after reaching a maximum diameter of 0.5 mm, with characteristics that emulate the action of pulsed lasers in said conducting medium.