Lesion and ulcer medication

• US 6,352,711 B1
• Filed: 11/30/1999
• Issued: 03/05/2002
• Est. Priority Date: 11/30/1999
• Status: Expired due to Term

• Current Assignee: Phillip Campbell
• Original Assignee: Phillip Campbell
• Inventors: Campbell, Phillip
• Primary Examiner(s): TATE, CHRISTOPHER ROBIN
• Application Number:
  US09/451,608
• Time in Patent Office: 826 Days
• Field of Search: 424/195.1, 424/434, 424/435, 424/485, 424/195.18, 514/925, 514/928
• US Class Current: 424/435
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Abstract

Pharmaceutical compositions are provided which comprise effective amounts of antimicrobials, anti-inflammatories, and antihistamines, to provide an ulcer medication which prevents secondary infections and promotes healing while providing immediate relief from pain. The composition may be used to treat a variety of ulcers including but not limited to intraoral aphthous ulcers and non-oral lesions.

Claims

1. A mucoadhesive pharmaceutical composition for treatment of intraoral ulcers comprising an antimicrobial component, dexamethasone, and diphenhydramine, wherein

the antimicrobial component comprises between 25 and 95 weight percent of the active ingredients,

the dexamethasone comprises between 0.02 and 0.75 weight percent of the active ingredients, and

the diphenhydramine comprises between 0.45 and 11 weight percent of the active ingredients.

2. A composition as in claim 1 further comprising metronidazole.

3. A composition as in claim 2 wherein the metronidazole comprises between 5 and 65 weight percent of the active ingredients.

4. A composition as in claim 2 further comprising karaya gum.

5. A composition as in claim 1 wherein the antimicrobial component comprises tetracycline.

6. A composition as in claim 1 wherein the antimicrobial component comprises zinc oxide which is present in an amount between 2.4 and 36 weight percent of the active ingredients.

7. A composition as in claim 1 further comprising at least one antibacterial agent effective against anaerobic bacteria.

8. A composition as in claim 7 wherein said at least one antibacterial agent effective against anaerobic bacteria comprises metronidazole.

9. A composition as in claim 1 further comprising an anesthetic component.

10. A composition as in claim 9 wherein said anesthetic is benzocaine.

11. A composition as in claim 1 wherein the antimicrobial agent comprises a penicillin based antimicrobial agent.

12. A mucoadhesive pharmaceutical composition for treatment of intraoral ulcers comprising 500 parts tetracycline HCl, 1 part dexamethasone, 17 parts diphenhydramine, and 67 parts zinc oxide.

13. A composition as in claim 12 further comprising 125 parts metronidazole.

14. A composition as in claim 12 further comprising 350 parts karaya gum.