System for the creation of patient specific templates for epileptiform activity detection

• US 6,353,754 B1
• Filed: 04/24/2000
• Issued: 03/05/2002
• Est. Priority Date: 04/24/2000
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Harwood, Jonathan P., Fischell, David R.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US09/556,415
• Time in Patent Office: 680 Days
• Field of Search: 600/544, 600/545
• US Class Current: 600/544
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy

Abstract

An epileptiform activity patient template creation system is provided which permits the user to efficiently develop an optimized set of patient specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed to a computer software package which operates within a computer workstation having a processor, disk storage and display for storing, processing and displaying patient EEG signals. The computer processor in conjunction with the software package allows for the marking of the initiation/termination of electrographic seizures within the patient'"'"'s displayed EEG signals. Epileptiform activity segments are extracted from at least one of the EEG signals with the activity segments including a marked initiation of a seizure. Subsequently, a seizure data set simultaneously displaying a number of the epileptiform activity segments is shown on the display monitor. Epileptiform activity is then detected from the displayed segments by an epileptiform activity detection algorithm having at least one programmable epileptiform activity detection parameter. The template is then created and modified to optimize epileptiform activity detection. The final template can then be downloaded to an implantable neuropacemaker for epileptic seizure control through responsive stimulation.

Claims

1. A system for formation and testing of a template for the detection of epileptiform activity from a patient'"'"'s brain comprising:

a computer workstation having processor means, disk storage means and display means for storing, processing and display of a multiplicity of EEG signals;

said processor means including;

means for marking an initiation and termination of electrographic seizures within said multiplicity of displayed EEG signals;

means for extracting epileptiform activity segments from at least one EEG signal, each of said epileptiform activity segments including a marked initiation of each of said electrographic seizures;

means for simultaneously displaying a seizure data set having a multiplicity of said epileptiform activity segments on said display means;

means for detecting epileptiform activity having at least one programmable epileptiform activity detection parameter; and

,

means for creation and modification of a template for epileptiform activity detection, said template including patient specific data parameters.

2. The system for formation and testing of a template as recited in claim 1 wherein said patient specific data parameters include the selection of at least one of said multiplicity of said EEG signals processed for epileptiform activity detection.

3. A system for formation and testing of a template as recited in claim 1 wherein said patient specific data parameters include a predetermined epileptiform activity detection parameter applied by said means for detecting said epileptiform activity.

4. The system for formation and testing of a template as recited in claim 1 wherein said multiplicity of EEG signals are stored in EEG files, said seizure data set including epileptiform activity segments from at least two EEG files.

5. The system for formation and testing of a template as recited in claim 1 wherein said computer workstation processor means displays said multiplicity of marked epileptiform activity segments in substantially aligned and vertically ascending position on said display means.

6. The system for formation and testing of a template as recited in claim 1 wherein said processor means includes means for iteratively testing a multiplicity of seizure detection templates, said processor means further including means for displaying an optimized set of templates wherein said optimization is determined by said iterative testing by said processor means.

7. The system for formation and testing of a template as recited in claim 1 wherein said means for detecting epileptiform activity, detects said epileptiform activity on a process display channel formed from at least one of said EEG signals.

8. The system for formation and testing of a template as recited in claim 1 wherein said means for detecting epileptiform activity detects said epileptiform activity on a process display channel formed by summing at least two of said EEG signals.

9. The system for formation and testing of a template as recited in claim 1 wherein said means for detecting epileptiform activity detects said epileptiform activity on a process display channel formed from a signal wherein a first EEG signal is subtracted from at least a second EEG signal.

10. The system for formation and testing of a template as recited in claim 1 wherein said means for detecting epileptiform activity includes means for detecting wave forms.

11. The system for formation and testing of a template as recited in claim 5 wherein said processor means includes means for aligning said initiation of each of said marked seizure segments as displayed in substantially vertical alignment on said display means.

12. The system for formation and testing of a template as recited in claim 11 wherein said processor means includes means for providing a vertical seizure start line for display and highlighting said substantially vertically aligned initiations of each seizure segment on said display means.

13. The system for formation and testing of a template as recited in claim 1 wherein said processor means includes means for manually inserting said seizure detection parameters for input to said processor means for detecting epileptiform activity.

14. The system for formation and testing of a template as recited in claim 13 wherein said processor means further includes means for testing said manually entered set of seizure detection parameters for determining the initiation of said electrographic seizures.

15. A system for formation and testing of a template for the detection of epileptiform activity from a patient'"'"'s brain comprising:

a computer workstation having processor means, disk storage means, and display means for storing, processing and displaying a multiplicity of EEG signals;

said processor means including;

means for marking an initiation and termination of electrographic seizures within said multiplicity of said displayed EEG signals;

means for extracting epileptiform activity segments from at least one EEG signal, each of said epileptiform activity segments including a marked initiation of each of said electrographic seizures; and

,

means for detecting epileptiform activity having at least one programmable epileptiform activity detection parameter.

16. The system for formation and testing of a template as recited in claim 15 wherein said processor means further includes means for simultaneously displaying a seizure data set having a multiplicity of said epileptiform activity segments on said display means.

17. The system for formation and testing of a template as recited in claim 15 wherein said processor means further includes means for forming and modifying said template for epileptiform activity detection from patient specific data parameters derived from said EEG signals.

18. The system for formation and testing of a template as recited in claim 17 wherein said patient specific data parameters include the selection of at least one of said multiplicity of said EEG signals being processed for epileptiform activity detection.

19. The system for formation and testing of a template as recited in claim 16 wherein said patient specific data parameters include a predetermined epileptiform activity detection parameter applied by said means for detecting said epileptiform activity.

20. The system for formation and testing of a template as recited in claim 18 wherein said multiplicity of EEG signals are stored in EEG files, said seizure data set including epileptiform activity segments from at least two of said EEG files.

21. The system for formation and testing of a template as recited in claim 15 wherein said computer workstation processor means includes means for displaying said multiplicity of marked epileptiform activity segments in substantially vertical alignment on said display means.

22. The system for formation and testing of a template as recited in claim 21 wherein said processor means provides means for aligning the initiation of each marked seizure segment being displayed in vertically consecutive alignment on said display means.

23. The system for formation and testing of a template as recited in claim 22 wherein said processor means includes means for forming a seizure start line highlighted on said display means for highlighting the aligned in initiation of each said seizure segment on said display means.

24. A system for formation and testing of a template for the detection of epileptiform activity from a patient'"'"'s brain comprising:

a computer workstation having processor means, disk storage means and display means for storing, processing and displaying a multiplicity of EEG signals;

said processor means including;

means for marking an initiation and termination of electrographic seizures within said multiplicity of displayed EEG signals; and

,

means for extracting epileptiform activity segments from at least one EEG signal, each of said epileptiform activity segments including a marked initiation of each of said electrographic seizures.

25. The system for formation and testing of a template as recited in claim 24 including means for detecting epileptiform activity having at least one programmable epileptiform activity detection parameter.

26. The system for formation and testing of a template as recited in claim 24 wherein said processor means further includes means for simultaneously displaying a seizure data set having a multiplicity of said epileptiform activity segments on said display means.

27. The system for formation and testing of a template as recited in claim 25 wherein said processor means further includes means for forming and modifying said template for epileptiform activity detection from patient specific data parameters derived from said EEG signals.

28. The system for formation and testing of a template as recited in claim 27 wherein said patient specific data parameters include portions of at least one of said multiplicity of said EEG signals being processed for epileptiform activity detection.

29. The system for formation and testing of a template as recited in claim 27 wherein said patient specific data parameters include a predetermined epileptiform activity detection parameter applied by said means for detecting said epileptiform activity.

30. The system for formation and testing of a template as recited in claim 28 wherein said multiplicity of EEG signals are stored in EEG files, said seizure data set including epileptiform activity segments from at least two of said EEG files.

31. The system for formation and testing of a template as recited in claim 24 wherein said computer workstation processor means includes means for displaying said multiplicity of marked epileptiform activity segments in substantially vertical alignment on said display means.

32. The system for formation and testing of a template as recited in claim 31 wherein said processor means provides means for aligning the initiation of each marked seizure segment being displayed in vertically consecutive alignment on said display means.

33. The system for formation and testing of a template as recited in claim 32 wherein said processor means includes means for forming a seizure start line highlighted on said display means for highlighting the aligned initiation of each said seizure segment on said display means.

34. A method for the formation of a template for the detection of epileptiform activities from a patient'"'"'s brain including the steps of:

acquiring a multiplicity of EEG signals from said patient'"'"'s brain;

storing said multiplicity of said EEG signals in at least one EEG file in a computer workstation having processor means, disk storage means and display means for storing, processing and display of a multiplicity of EEG signals;

determining the initiation and termination of electrographic seizures in said EEG signals stored in said at least one EEG file;

marking said initiation and termination of said electrographic seizures in said EEG signals in said at least one EEG file;

establishing seizure data segments extracted from said at least one EEG signal wherein each of said segments includes said marked initiation of said electrographic seizure; and

,

displaying said seizure data segments on said display means of said computer workstation.

35. The method for development of a template as recited in claim 34 wherein said step of establishing said seizure data segments includes the step of processing said seizure data set for determination of epileptiform activity detection.

36. The method for development of a template as recited in claim 35 wherein said step of storing said multiplicity of EEG signals is followed by the step of processing said at least one EEG file for determination of a epileptiform activity within said EEG signals.

37. The method for the development of a template as recited in claim 36 wherein said processing of said at least one EEG file includes the step of identifying false positive detections.

38. The method for the development of a template as recited in claim 37 wherein said step of identifying false positive detections includes the step of detection of epileptiform activity external to the range of said initiation and termination of said electrographic seizures.

39. The method for the development of a template as recited in claim 35 including the step of processing at least one of said multiplicity of EEG signals for determining an epileptic seizure.

40. The method for the development of a template as recited in claim 35 wherein said step of displaying said seizure data set includes the step of aligning each of said seizure data segments in a vertical manner on said display means.

41. The method for the development of a template as recited in claim 35 wherein the step of displaying said seizure data includes the step of marking the initiation of the electrographic seizures in said segments of said seizure data set.