Method for storing and retrieving sequential information
First Claim
1. A method for testing the effects of drugs or treatment on a biological memory system of a subject, comprising monitoring the subject'"'"'s neural function to determine whether the drug or treatment improves or impairs the ability of a subject to store or retrieve sequential memories, comprising the steps of:
- i) administering the drug or treatment to the subject;
ii) generating sequential activity in the neural system of said subject with an electrical stimulation electrode or other recognized method of inducing neural activity at a predetermined frequency or temporal pattern;
iii) monitoring whether the frequency or temporal pattern is faithfully transmitted;
iv) monitoring whether the neural activity generated at multiple recording electrodes show a consistent sequence on successive stimulation pulses or trains of pulses;
v) determining efficacy of the drug or treatment by comparing the faithfulness of the transmitted frequency or temporal pattern obtained for the individual before and after the administration of the drug or treatment; and
vi) determining efficacy of the drug or treatment by comparing the sequence of neural activity generated at multiple recording electrodes by successive stimulation pulses or trains of pulses before and after the administration of the drug or treatment.
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Abstract
A method and design is provided for distributing and storing sets of temporally ordered information in a systematic and sequential fashion. This method is based on a model of how the brain functions in the distribution and storage of temporally ordered memories, but it can also be applied to the design of new biological, electronic or optical devices. These devices may be used in the testing and development of new therapeutic drugs, in the detection of toxic agents or impaired performance, or in the development of new industrial and consumer devices in which the orderly storage of sequential information is important.
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Citations
10 Claims
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1. A method for testing the effects of drugs or treatment on a biological memory system of a subject, comprising monitoring the subject'"'"'s neural function to determine whether the drug or treatment improves or impairs the ability of a subject to store or retrieve sequential memories, comprising the steps of:
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i) administering the drug or treatment to the subject;
ii) generating sequential activity in the neural system of said subject with an electrical stimulation electrode or other recognized method of inducing neural activity at a predetermined frequency or temporal pattern;
iii) monitoring whether the frequency or temporal pattern is faithfully transmitted;
iv) monitoring whether the neural activity generated at multiple recording electrodes show a consistent sequence on successive stimulation pulses or trains of pulses;
v) determining efficacy of the drug or treatment by comparing the faithfulness of the transmitted frequency or temporal pattern obtained for the individual before and after the administration of the drug or treatment; and
vi) determining efficacy of the drug or treatment by comparing the sequence of neural activity generated at multiple recording electrodes by successive stimulation pulses or trains of pulses before and after the administration of the drug or treatment. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method, based on the sequential spatial distribution model of temporal memory, for testing the effects of drugs, treatments, genetic state or other biological conditions on a biological memory system of a subject being treated with drugs, comprising monitoring the subject'"'"'s neural function to determine whether the drug, treatment, genetic state or biological state improves or impairs the ability of a subject to store or retrieve sequential memories, comprising the steps of:
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i) generating sequential activity in the neural system of said subject with an electrical stimulation electrode or other recognized method to induce neural activity at a predetermined frequency or temporal pattern;
ii) monitoring whether the frequency or temporal pattern is faithfully transmitted between different electrodes or neural foci;
iii) monitoring whether brain neural activity levels induced by one or more stimulating devices shows a systemic incrementing shift in spatial distribution peak and through activity along fiber pathways of information flow;
iv) monitoring whether neural activity generated at each brain site shows a consistent sequence of waxing and waning activity on successive stimulation pulses or trains of pulses;
v) determining efficacy of the drug, treatment, genetic state or biological state by comparing the faithfulness of the transmitted frequency, temporal pattern or spatial distribution obtained for the individual before and after the administration of the drug or treatment or between individuals with different genetic or biological states; and
vi) determining efficacy of the drug, treatment, genetic state or biological state by comparing the sequence of neural activity generated at multiple recording electrodes, photoreceptors or other sensors of neural activity by successive stimulation pulses or trains of pulses before and after the administration of the drug or treatment or the induction of a genetic or biological state; and
vii) providing instrumentation, algorithms, software or procedures for specifically monitoring the above parameters. - View Dependent Claims (8, 9, 10)
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Specification