Adjustable electrotransport drug delivery using a fixed output controller
First Claim
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1. A method for delivering a therapeutic agent through a body surface, comprising the steps of:
- delivering the therapeutic agent through the body surface from an electrotransport assembly of the type which includes a controller component and a detachable therapeutic agent source coupled to the controller component, the controller component operating at a predetermined, fixed electrical output; and
adjusting the rate of therapeutic agent delivery by uncoupling the therapeutic agent source from the controller component and coupling each of a plurality of therapeutic agent sources in which a single parameter or a series of parameters has been varied so that agent delivery rate is selectively controllable by coupling and uncoupling said plurality of therapeutic agent sources to the controller component one at a time.
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Abstract
The invention provides a method for adjusting, i.e., varying, the rate of delivery of a therapeutic agent through a body surface from an electrotransport assembly of the type which includes a predetermined, e.g., fixed, output electronic controller and a detachable therapeutic agent source. The method provides a plurality of therapeutic agent sources in which a single parameter or a series of parameters has been varied. The plurality of agent sources are supplied, one at a time, to the controller of the electrotransport assembly, so that together (i.e., source and controller) the agent delivery rate is varied.
49 Citations
28 Claims
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1. A method for delivering a therapeutic agent through a body surface, comprising the steps of:
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delivering the therapeutic agent through the body surface from an electrotransport assembly of the type which includes a controller component and a detachable therapeutic agent source coupled to the controller component, the controller component operating at a predetermined, fixed electrical output; and
adjusting the rate of therapeutic agent delivery by uncoupling the therapeutic agent source from the controller component and coupling each of a plurality of therapeutic agent sources in which a single parameter or a series of parameters has been varied so that agent delivery rate is selectively controllable by coupling and uncoupling said plurality of therapeutic agent sources to the controller component one at a time. - View Dependent Claims (2, 3, 4, 5)
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6. A method for varying drug delivery rate of a therapeutic agent through a body surface, comprising the steps of:
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delivering the therapeutic agent through the body surface from an electrotransport assembly of the type which includes an electronic controller component and a detachable drug-containing unit coupled to the controller component, the drug-containing unit having an active electrode, the controller component operating at a fixed output; and
uncoupling the drug-containing unit from the controller component and coupling, one at a time, a plurality of drug-containing units to the controller component, each drug-containing unit having a specific dose different from the others of said plurality and coupling and uncoupling said drug-containing unit to the controller component thereby varying drug delivery rate. - View Dependent Claims (7, 8, 9, 10)
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11. An electrotransport device for delivering a therapeutic agent through a body surface, the device including a controller which operates at a predetermined, fixed electrical output, the controller being adapted to be detachably connected, one at a time, to a plurality of therapeutic agent sources, the device having:
a plurality of different classes of therapeutic agent sources in which a parameter in each of said different classes has been varied so that the electrotransport agent delivery rate from the controller with one class of therapeutic agent sources is substantially different from the controller with another of said classes of therapeutic agent sources. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of delivering a therapeutic agent through a body surface from an electrotransport assembly of the type which includes a controller component and a detachable therapeutic agent source, the controller component operating at a predetermined, fixed electrical output, the method comprising the steps of:
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providing a plurality of therapeutic agent sources in which a single parameter or a series of parameters has been varied so that, in conjunction with said controller component, agent delivery rate can be selectively controlled by coupling and uncoupling said therapeutic agent sources to the controller component; and
interchanging said agent sources whereby therapeutic agent delivery rate is selectively controlled at fixed controller-component electrical output.
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22. An electrotransport delivery system comprising:
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an electrotransport device for delivering a therapeutic agent through a body surface, the device including a controller which operates at a predetermined, substantially fixed electrical output, the controller being adapted to be detachably connected to a plurality of therapeutic agent sources; and
a plurality of different therapeutic agent sources in which a parameter in each said different sources has been varied so that electrotransport agent delivery rate from the system with one of said sources is substantially different from the electrotransport agent delivery rate from the system with another of said sources. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification