Follistatin-related protein zfsta2

• US 6,355,788 B1
• Filed: 10/05/1999
• Issued: 03/12/2002
• Est. Priority Date: 10/15/1998
• Status: Expired due to Fees

• Current Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company)
• Original Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company)
• Inventors: Ellsworth, Jeff L., Conklin, Darrell C.
• Primary Examiner(s): Eyler, Yvonne
• Assistant Examiner(s): Andres, Janet L.
• Application Number:
  US09/412,554
• Time in Patent Office: 889 Days
• Field of Search: 536/23.5, 536/23.4, 435/69.1, 435/69.7, 530/320, 530/324, 514/2
• US Class Current: 536/23.4
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/4703 Inhibitors; Suppressors
• CPC Class Codes: C07K 2319/02 containing a signal sequence

Abstract

The present invention relates to polynucleotide and polypeptide molecules for zfsta2, a novel member of the follistatin family. The polypeptides, and polynucleotides encoding them are useful for binding to members of the TGF-β family and mediating central nervous system, reproductive, hematopoietic and bone-related activities. The present invention also includes antibodies to the zfsta2 polypeptides.

Claims

1. A polynucleotide encoding a fusion protein comprising a secretory signal sequence having the amino acid sequence of amino acid residues 1-20 of SEQ ID NO:

2, wherein said secretory signal sequence is operably linked to the amino terminal of an additional polypeptide.