Assessment of cardiovascular performance using ultrasound methods and devices that interrogate interstitial fluid
First Claim
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1. A method of monitoring cardiovascular performance in a subject, comprising:
- a) positioning an ultrasound probe on an epidermal surface of a first appendage region of a subject in need of cardiovascular performance assessment and said subject is optionally suspected of comprised or challenged cardiac, arterial, or venous function, b) applying at least one ultrasound pulse to a subcutaneous layer of said first appendage region, c) recording a least one ultrasound signal with said ultrasound probe from said first appendage region, and d) detecting an interstitial fluid layer in said subcutaneous layer of said first appendage region from said at least one ultrasound signal; and
wherein detecting said interstitial fluid layer is an assessment of cardiovascular function.
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Abstract
The present invention provides for methods and devices for monitoring cardiovascular performance. The invention also includes methods of measuring capillary related interstitial fluid, as well as cardiac and vascular function. Specific devices, particularly probes, are provided for such methods.
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Citations
20 Claims
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1. A method of monitoring cardiovascular performance in a subject, comprising:
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a) positioning an ultrasound probe on an epidermal surface of a first appendage region of a subject in need of cardiovascular performance assessment and said subject is optionally suspected of comprised or challenged cardiac, arterial, or venous function, b) applying at least one ultrasound pulse to a subcutaneous layer of said first appendage region, c) recording a least one ultrasound signal with said ultrasound probe from said first appendage region, and d) detecting an interstitial fluid layer in said subcutaneous layer of said first appendage region from said at least one ultrasound signal; and
wherein detecting said interstitial fluid layer is an assessment of cardiovascular function. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
a) administering a diuretic agent, a cardiac agent or a diabetic agent, b) positioning an ultrasound probe on an appendage region of a subject in need of cardiovascular assessment after said administration, and c) recording ultrasound signals with said ultrasound probe from said appendage region;
d) wherein said ultrasound signals can be used to measure a capillary related edema layer in said appendage region after said administration.
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10. The method of claim 5, wherein said ultrasound probe is an autonomous, hand-held ultrasound system capable of self-measurement.
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11. A method of assessing vascular performance, comprising:
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a) reducing or increasing blood flow or pressure to a tissue in a subject, b) monitoring a capillary related interstitial layer thickness of said tissue with an ultrasound probe after or concurrent with said step (a), c) increasing said blood flow to said tissue after said reducing in step (a) and said monitoring in step (b) or decreasing said blood flow to said tissue after said increasing in step (a) and said monitoring in step (b), and d) monitoring said capillary related interstitial layer thickness of said tissue with an ultrasound probe, after or concurrent with said step (c), wherein said reduction in blood flow controllably reduces blood flow to said tissue for a clinically relevant period of time in step (a) and said increase in blood flow controllably increases blood flow to said tissue for a clinically relevant period of time in step (c), or wherein said increase in blood flow controllably increases blood flow to said tissue for a clinically relevant period of time in step (a) and said reduction in blood flow controllably reduces blood flow to said tissue for a clinically relevant period of time in step (c).
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12. A method for non-invasively estimating dynamic cardiac performance in a human, comprising:
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a) monitoring interstitial fluid content with an ultrasound probe positioned on the skin of a human in need of cardiac performance evaluation and in an anatomical region suitable for monitoring changes in interstitial fluid content during a clinically relevant time period, and b) comparing said capillary related interstitial fluid content monitored in step (a) with a standard value for capillary related interstitial fluid content or with a measurement of capillary related interstitial fluid content in said human. - View Dependent Claims (13, 14, 15)
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- 16. A system for monitoring cardiovascular performance, comprising a heart electrical signal detection device and an ultrasound interstitial layer detection device for monitoring cardiovascular performance.
Specification